Evaluation of Biological Effects of Nanosystems of Directed Transport in Experiments in Vivo and Their Application Possibilities in Anti-Tumor Therapy

Vasyl F. Chekhun, Lesia A. Naleskina, Liudmila Z. Polishchuk, Igor M. Todor, Dmytro V. Demash, Natalia Yu. Lukianova

Department of Mechanisms of Anti-Tumor Therapy, RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of National Academy of Sciences of Ukraine, Kyiv, Ukraine.

DOI: 10.4236/anp.2013.22023                

Abstract

The aim of the investigations was to evaluate benefits of the directed transport system - a nanocomposite, based on cisplatin and magnetite combined with local action of constant magnetic field on the tumor, in experiments in vivo in animals with transplantable Guerin carcinoma. Animals were divided into 5 groups according to the type of agent. We showed that nanocomposite in combination with static magnetic field exercises more prominent anti-tumor activity than cisplatin alone. It should be noted that regardless of the therapeutic agent, in Guerin carcinoma we observed

Keywords

Oncology; Nanocomposite; Static Magnetic Field; Cisplatin; Anti-Tumor Activity; Guerin Carcinoma

Conflicts of Interest

The authors declare no conflicts of interest.

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