Synthesis of Some N-[(4-Substituted-1-Piperazinyl)-Oxo(Alkyl and Ethylcarbamoyl)]-3-(2-Thiophenyl)Acrylamides as Non-Steroidal Anti-Allergic and Anti-Inflammatory Agents

Osama I. Abd El-Salam, Ahmed M. Shalaby, Abdulah A. El-Sawy, Soha Elshihaby, Mohamed Abdulla

Department of Applied Organic Chemistry, National Research Centre, Cairo, Egypt.
Department of Chemistry, Faculty of Science, Benha University, Banha, Egypt.
Department of Peptide Chemistry, National Research Centre, Cairo, Egypt.
Research Units, Hi-Care Pharmaceutical Co., Cairo, Egypt.

DOI: 10.4236/ojsta.2013.22008                

Abstract

An interesting approach for the design of anti-allergies is rationally considered. It was proved that current anti-allergic drugs comprise piperazine and acrylic acid segments. In harmony with these findings, new products 5a-u were synthesized starting from conjugated 2-thiopheneacrylic acid with amino acid esters3a-g followed by coupling of their acid derivatives4a-g with some piperazine segments, with the aim to increase their biological activities and decrease side effects. The anti-allergic and anti-inflammatory activities of the products were evaluated and promising results were obtained.

Keywords

Thiophene; Amino Acids; Piperazines; Anti-Allergy; Ant-Inflammatory

Conflicts of Interest

The authors declare no conflicts of interest.

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