A Case of Severe Hypomagnesaemia

Abstract

Hypomagnesaemia is a common finding that occurs in hospitalised patients and can be caused by renal or extrarenal wasting. Because it is not routinely tested, even severe hypomagnesaemia can be missed. In cases of extrarenal wasting, the kidney can decrease its magnesium excretion to very low levels. A systematic diagnostic approach allows the proper diagnosis and treatment of hypomagnesaemia. We report on a 72-year-old Caucasian male patient with repeated drops and amyosthenia caused by severe hypomagnesaemia. In this report, we discuss the pathophysiology, clinical signs, diagnostic investigation and treatment of magnesium depletion.

Share and Cite:

Anand, G. , Konrad, M. , Heuss, L. and Schorn, R. (2013) A Case of Severe Hypomagnesaemia. Open Journal of Nephrology, 3, 66-69. doi: 10.4236/ojneph.2013.31011.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] E. T. Wong, R. K. Rude, F. R. Singer, S. T. Shaw Jr., “A High Prevalence of Hypomagnesemia and Hypermagnesemia in Hospitalized Patients,” American Journal of Clinical Pathology, Vol. 79, No. 3, 1983, pp. 348-352.
[2] G. M. Tong and R. K. Rude, “Magnesium Deficiency in Critical Illness,” Journal of Intensive Care Medicine, Vol. 20, No. 1, 2005, 20, pp. 3-17.
[3] W. Jahnen-Dechent and M. Ketteler, “Magnesium Basics,” Clinical Kidney Journal, Vol. 5, Suppl. 1, 2012, pp. i3-i14. doi:10.1093/ndtplus/sfr163
[4] J. H. F. De Baaij, J. G. J. Hoendderop and R. J. M. Bindels, “Regulation of Magnesium Balance: Lessons Learned from Human Genetic Disease,” Clinical Kidney Journal, Vol. 5, Suppl. 1, 2012, pp. i15-i24.
[5] L. A. Graham, J. J. Caesar and A. S. Burgen, “Gastrointestinal Absorption and Excretion of Mg28 in Man,” Metabolism, No. 9, 1960, pp. 646-659.
[6] B. Glaudemans, N. V. Knoers, J. G. Hoenderop and R. J. M. Bindels, “New Molecular Players Facilitating Mg2+ Reabsorption in the Distal Convoluted Tubule,” Kidney International, Vol. 77, No. 1, 2010, pp. 17-22. doi:10.1038/ki.2009.358
[7] Z. S. Agus, “Hypomagnesemia,” Journal of the American Society of Nephrology, Vol. 10, No. 7, 1999, pp. 168-174.
[8] G. Regolisti, A. Cabassi, E. Parenti, U. Maggiore and E. Fiaccadori, “Severe Hypomagnesemia during Long-Term Treatment with a Proton Pump Inhibitor,” American Journal of Kidney Diseases, Vol. 56, No. 1, 2010, pp. 168-174. doi:10.1053/j.ajkd.2010.03.013
[9] N. V. Knoers, “Inherited Forms of Renal Hypomagnesemia: An Update,” Pediatric Nephrology, Vol. 24, No. 4, 2009, pp. 695-705. doi:10.1007/s00467-008-0968-x
[10] M. Elisaf, K. Panteli, J. Theodorou and K. C. Siamopoulos, “Fractional Excretion of Magnesium in Normal Subjects and in Patients with Hypomagnesemia,” Magnesium Research, Vol. 10, No. 4, 1997, pp. 315-320.
[11] P. Hébert, N. Mehta, J. Wang, T. Hindmarsh, G. Jones and P. Cardinal, “Functional Magnesium Deficiency in Critically Ill Patients Identified Using a Magnesium-Loading Test,” Critical Care Medicine, Vol. 25, No. 5, 1997, pp. 749-755.
[12] R. Whang and K. W. Ryder, “Frequency of Hypomagnesemia and Hypermagnesemia. Requested vs Routine,” Journal of the American Medical Association, Vol. 263, No. 22, 1990, pp. 3063-3064

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.