Estimation of GFR by MDRD Formula and Its Correlation to Cockcroft-Gault Equation in Five Stages of Chronic Kidney Disease

Absar Ali, Naila Asif, Zunaira Rais

Department of Medicine, Aga Khan University, Karachi, Pakistan.
Liaquat National Hospital, Karachi, Pakistan.

DOI: 10.4236/ojneph.2013.31006                

Abstract

Background: Purpose of our study was to find out correlation between estimated Glomerular Filtration Rate (GFR) by Modification of Diet in Renal Disease (MDRD) formula and Glomerular Filtration Rate by Cockcroft-Gault equations, in patients with chronic kidney disease (CKD), and to see whether they can be used interchangeably. Methods: We conducted a cross section study of 70 patients presented to the nephrology clinic over a period of one year. We compared the Glomerular Filtration Rate by these two formulas in five stages of Chronic Kidney Disease. Abbreviated 4 variable Modification of Diet in Renal Disease formula was used.Results: Age range was 15 - 79 years; Male 49%, Female 51%. The correlation (r) between eGFR by MDRD and eGFR by Cockcroft-Gault equation for CKD stages 1 to 5 was 0.64; 0.31; 0.32; 0.67; and 0.45 respectively. The correlation (r) between creatinine clearance by 24 hour urine collection and MDRD formula was 0.84 (P: 0.001). The correlation (r) between creatinine clearance by 24 hour urine collection Cockcroft-Gault equation was 0.79 (P: 0.001). Conclusion: We conclude that Cockcroft-Gault equation correlates best with MDRD formula at CKD stages 4 and one. Cockcroft-Gault equation underestimated eGFR in stages 1, 2 and 3 of chronic Kidney Disease.

Keywords

MDRD; Cockcroft-Gault; Chronic Kidney Disease; CKD

Conflicts of Interest

The authors declare no conflicts of interest.

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