Tissue Engineering: From Bench to Bed Side Exemples of Applications

J-F. Stoltz, C. Huselstein, D. Bensoussan, N. de Isla, V. Decot

CNRS UMR 7561, Biop?le, Faculté de Médecine – Université Lorraine.
CNRS UMR 7561, Biop?le, Faculté de Médecine – Université Lorraine,.
CNRS UMR 7561, Biop?le, Faculté de Médecine – Université Lorraine, 54500 VANDOEUVRE LES NANCY, France 54500 2CHU de Nancy, UTCT, Brabois,.
CNRS UMR 7561, Biop?le, Faculté de Médecine – Université Lorraine,54500 VANDOEUVRE LES NANCY, France 54500.

DOI: 10.4236/eng.2012.410B011                

Abstract

Tissue engineering is an emerging multidisciplinary field involving surgery medicine, biology, chemistry, mechanics and engineering to improve the health and quality of life by restoring, maintaining or enhancing tissue and organ function [6;11]. The principle is simple: cells are collected and introduced -with or without modification of their biological properties- into an environment in which physico-chemical and mechanical parameters are kept stable. When they reach maturity, the biotissue or cells can be grafted. The main parameters are: cells, scaffold, biological molecules and mechanical forces. A combination of these parameters can promote cellular differentiation and proliferation. But it should be emphasized that at this time, signalling pathways and the rationale behind the physiological design remain to be elucidated. Among the main medium-term clinical applications are cardiac insufficiency, atherosclerosis, osteoarthritis, diabetes, liver diseases, bladder, and skin. In this paper the examples of cartilage and vascular engineering will be examined.

Keywords

Tissue Engineering; Stem Cells; Scaffolds

Conflicts of Interest

The authors declare no conflicts of interest.

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