The prevention of oxidative stress improve asthmatic inflammation

Anita Nishiyama, Ana Lúcia Zanatta, Pedro Vicente Michelotto Junior

Department of Physiology, Federal University of Paraná, Curitiba, Brazil.
School of Agricultural Sciences and Veterinary Medicine, Pontifical Catholic University of Paraná, S?o José dos Pinhais, Brazil.

DOI: 10.4236/abb.2012.38132                

Abstract

Asthma is a disease characterized by airway chronic inflammation and bronchial hyperactivity, involving the imbalance of oxidative and antioxidative agents. There is an increased free radical generation and a decreased antioxidant enzyme activity, which correlate with the severity of the disease. The oxidative stress triggers specific physiopathological changes in the respiratory tract as a result of proinflammatory molecule formation, such as isoprostanes and PAF- like lipids. The synthesis of these mediators is dependent on the availability of lipid substrates, such as PUFAs, which are present in cell membranes. Therefore, lipid oxidation may have an important role in the perpetuation and amplification of the asthmatic inflammatory response. This article will make considerations about how oxidative stress contributes to asthma pathogenesis.

Keywords

Asthma; Oxidative Stress; Inflammation; Lipid Mediators

Conflicts of Interest

The authors declare no conflicts of interest.

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