Gastric Neuroendocrine Carcinoma in a Dog

Nadja Herbach, Stefan Unterer, Walter Hermanns

Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University of Munich, Munich, German.
Institute of Veterinary Pathology, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University of Munich, Munich, Germany.

DOI: 10.4236/ojpathology.2012.24031                

Abstract

A gastric biopsy specimen from a 14-year-old Yorkshire terrier was analysed using light microscopy, immunohistochemistry and transmission electron microscopy. The biopsies were obtained from a 3 × 3 × 4 cm mass located at the gastric cardia. Light microscopy revealed solid nests and sheets of tumour cells separated by abundant fibrovascular stroma in all gastric layers. The tumour cells were monomorphic, with eosinophilic cytoplasm and demonstrated palisading at the periphery. Nuclei were round to oval with densely packed chromatin and inconspicuous nucleoli. The tumour cells immunohistochemically stained strongly positive for chromogranin A, synaptophysin, and pan-cytokeratin. Electron microscopy revealed electron dense neurosecretory granules of 100 - 150 nm in diameter. Metastases were found in regional lymph nodes. Gastric neuroendocrine carcinoma was diagnosed, according to the histological, immunohistochemical and electron microscopic features.

Keywords

Gastric Carcinoid, Gastric Neuroendocrine Carcinoma; Dog; Stomach

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	G. Kloppel, “Tumour Biology and Histopathology of Neuroendocrine Tumours,” Best Practice & Research: Clinical Endocrinology & Metabolism, Vol. 21, No. 1, 2007, pp. 15-31. doi:10.1016/j.beem.2007.01.004
[2]	K. W. Head, J. M. Cullen, R. R. Dubielzig, R. W. Else, W. Misdorp, A. K. Patnaik, S. Tateyama and I. van der Gaag, “Histological Classification of Gastric Tumors of Domestic Animals,” In: F. Y. Schulman, Ed., Histological Classification of Tumors of the Alimentary System of Domestic Animals, Armed Forces Institute of Pathology, Washington, 2003.
[3]	M. Kiupel, C. Capen, M. Miller and R. Smedley, “Tumors of Dispersed Endocrine Cells,” Armed Forces Institute of Pathology, Washington, 2008.
[4]	M. Schott, G. Kloppel, A. Raffel, A. Saleh, W. T. Knoefel and W. A. Scherbaum, “Neuroendocrine Neoplasms of the Gastrointestinal Tract,” Deutsches ?rzteblatt International, Vol. 108, No. 18, 2011, pp. 305-312.
[5]	G. Rindi, R. Arnold, F. T. Bosmann, C. Capella, D. S. Klimstra, G. Kloppel, P. Komminoth and E. Solcia, “Nomenclature and Classification of Neuroendocrine Neoplasms of the Digestive System,” In: F. T. Bosman, F. Carneiro, R. H. Hruban and N. D. Theise, Eds., WHO Classification of Tumours of the Digestive System, IARC, Lyon, 2010.
[6]	C. C. Brown, D. C. Baker and I. K. Barker, “Neoplastic and Proliferative Lesions of the Stomach and Intestine,” In: M. G. Maxie, Ed., Jubb, Kennedy and Palmer’s Pathology of Domestic Animals, W. B. Saunders, Edinburgh, 2007, pp. 116-128.
[7]	K. W. Head, R. W. Else and R. R. Dubielzig, “Tumors of the Alimentary Tract,” In: D. J. Meuten, Ed., Tumors in Domestic Animals, Iowa State Press, Iowa, 2002, pp. 401-481. doi:10.1002/9780470376928.ch8
[8]	G. Kloppel, A. Perren and P. U. Heitz, “The Gastroenteropancreatic Neuroendocrine Cell System and Its Tumors: The WHO Classification,” Annals of the New York Academy of Sciences, Vol. 1014, 2004, pp. 13-27. doi:10.1196/annals.1294.002
[9]	T. M. Albers, J. Alroy, J. J. McDonnell and A. S. Moore, “A Poorly Differentiated Gastric Carcinoid in a Dog,” Journal of Veterinary Diagnostic Investigation, Vol. 10, No. 1, 1998, pp. 116-118. doi:10.1177/104063879801000126
[10]	D. G. Penninck, A. S. Moore and J. Gliatto, “Ultrasonography of Canine Gastric Epithelial Neoplasia,” Veterinary Radiology & Ultrasound, Vol. 39, No. 4, 1998, pp. 342-348. doi:10.1111/j.1740-8261.1998.tb01618.x
[11]	G. Qvigstad, O. Kolbjornsen, E. Skancke and H. L. Waldum, “Gastric Neuroendocrine Carcinoma Associated with Atrophic Gastritis in the Norwegian Lundehund,” Journal of Comparative Pathology, Vol. 139, No. 4, 2008, pp. 194-201. doi:10.1016/j.jcpa.2008.07.001
[12]	O. Kolbjornsen, C. M. Press and T. Landsverk, “Gastropathies in the Lundehund. I. Gastritis and Gastric Neoplasia Associated with Intestinal Lymphangiectasia,” APMIS, Vol. 102, No. 9, 1994, pp. 647-661.
[13]	A. I. Baba and C. Catoi, “Comparative Oncology,” The Publishing House of the Romanian Academy, Bucharest, 2007.