[1]
|
[1] McInnes, I.B. and Schett, G. (2007) Cytokines in the pathogenesis of rheumatoid arthritis. Nature Reviews Immunology, 7, 429-442. doi:10.1038/nri2094
|
[2]
|
Van den Broek, T., Tesser, J.R.P. and Albani, S. (2008) The evolution of biomarkers in rheumatoid arthritis: From clinical research to clinical care. Expert Opinion on Biological Therapy, 8, 1773-1785.
doi:10.1517/14712598.8.11.1773
|
[3]
|
Devlin, J., Gough, A., Huisson, A., Perkins, P., Holder, R., Reece, R., et al. (1997) The acute phase and function in early rheumatoid arthritis, c-reactive protein levels correlate with functional outcome. Journal of Rheumatology, 24, 9-13.
|
[4]
|
Pepys, M.B. and Hirschfield, G.M. (2003), C-reactive protein: A critical update. Journal of Clinical Investigation, 111, 1805-1812.
|
[5]
|
Elliott, M.J, Maini, R.N., Feldmann, M., Kalden, J.R., Antoni, C., Smolen, J.S., et al. (1994) Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (Ca2) versus placebo in rheumatoid arthritis. Lancet, 344, 1105-1110.
doi:10.1016/S0140-6736(94)90628-9
|
[6]
|
Eklund, C.M. (2009), Proinflammatory cytokines in CRP baseline regulation. Advances in Clinical Chemistry, 48, 111-136. doi:10.1016/S0065-2423(09)48005-3
|
[7]
|
Guerne, P.A., Zuraw, B.L., Vaughan, J.H., Carson, D.A. and Lotz, M. (1989) Synovium as a source of interleukin 6 in vitro. Contributions to local and systemic manifestations of arthritis. Journal of Clinical Investigation, 83, 585-592. doi:10.1172/JCI113921
|
[8]
|
Perry, M.G., Kirwan, J.R., Jessop, D.S. and Hunt, L.P. (2009) Overnight variations in Coritisol, interleukin 6, tumour necrosis factor (alpha) and other cytokines in people with rheumatoid arthritis. Arthritis & Rheumatism, 68, 63-68. doi:10.1136/ard.2007.086561
|
[9]
|
Campbell, J., Ciesielski, C.J., Hunt, A.E., Horwood, N.J., Beech, J.T., Hayes, L.A., et al. (2004) A novel mechanism for TNF-alpha regulation by p38 MAPK: Involvement of NF-B with implications for therapy in rheumatoid arthritis. Journal of Immunology, 173, 6928-6937.
|
[10]
|
Cohen, S.B., Cheng., T.T., Chindalore, V., Damjanov, N., Burgos-Vargas, R., DeLora, P., et al. (2009) Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis. Arthritis & Rheumatism, 60, 335-344. doi:10.1002/art.24266
|
[11]
|
Damjanov, N., Kauffman, R.S. and Spencer-Green, G.T. (2009) Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: Results of two randomized, double-blind, placebo-con-trolled clinical studies. Arthritis & Rheumatism, 60, 1232-1241. doi:10.1002/art.24485
|
[12]
|
Genovese, M.C. (2009) Inhibition of p38: Has the fat lady sung? Arthritis & Rheumatism, 60, 317-320.
doi:10.1002/art.24264
|
[13]
|
Aston, N.M., Bamborough, P., Buckton, J.B., Edwards, C.D., Holmes, D.S., Jones, K.L., et al. (2009) p38(alpha) mitogen-activated protein kinase inhibitors: Optimization of a series of biphenylamines to give a molecule suitable for clinical progression. Journal of Medicinal Chemistry, 52, 6257-6269. doi:10.1021/jm9004779
|
[14]
|
Genovese M.C., Gao, L., Yin, J., Smith, S., Weinblatt, M.E., Smolen, J.S., et al. (2010) Proof of concept study for a potent p38 MAPK dual action inhibitor BMS-582949 in subjects with RA receiving comcomitant methotrexate, American College of Rheumatology (ACR).
|
[15]
|
Schieven, G., Zhang, R., Pitt, S., Shen, D.-R., Cao, J., Sack, J., et al. (2010) BMS-582949 is a dual action p38 kinase inhibitor well suited to avoid resistance mechanisms that increase p38 activation in cells, American College of Rheumatology (ACR).
|
[16]
|
Branger, J., van den BB, Weijer, S., Madwed, J., Bos, C.L., Gupta, A., et al. (2002) Anti-inflammatory effects of a p38 mitogen-activate inhibitor during human endotoxemia. Journal of Immunology, 168, 4070-4077.
|
[17]
|
Vertex Pharmaceuticals (2004) First demonstration of CRP reduction in cardiovascular patients using an oral cytokine inhibitor. PRNewswire-FirstCall, 18 October 2004.
|
[18]
|
Ding, C. (2006) Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome. Current Opinion in Investigational Drugs, 7, 1020-1025.
|
[19]
|
Dallegri, F. and Ottonello, L. (2002) Pharmacological implications in the switch from acute to chronic inflammation. Inflammaphamacology, 10, 159-171.
doi:10.1163/156856002321168187
|
[20]
|
Dominguez, C., Powers, D.A. and Tamayo, N. (2005) p38 MAP kinase inhibitors: Many are made, but few are chosen. Current Opinion in Drug Discovery & Development, 8, 420-430.
|
[21]
|
Kirwan, J.R., Hallgren, R., Mielants, H., Wollheim, F., Bjorck, E., Persson, T., et al. (2004) A randomized placebo controlled 12 week trial of budesonide and prednisolone in rheumatoid arthritis. Annals of the Rheumatic Diseases, 63, 688-695. doi:10.1136/ard.2003.008573
|
[22]
|
Grisar, J.C., Kapral, T., Gonda, G., Stamm, T., Smolen, J.S. and Aletaha, D. (2006) Short term responsiveness of biomarkers to prednisolone in patients with active rheumatoid arthritis. Annals of the Rheumatic Diseases, 65, 171.
|
[23]
|
Gerlag, D.M., Haringman, J.J., Smeets, T.J., Zwinderman, A.H., Kraan, M.C., Laud, P.J., et al. (2004) Effects of oral prednisolone on biomarkers in synovial tissue and clinical improvement in rheumatoid arthritis. Arthritis and Inflammation, 50, 3783-3791. doi:10.1002/art.20664
|
[24]
|
Rioja, I., Hughes, F.J., Sharp, C.H., Warnock, L.C., Montgomery, D.S., Akil, M., et al. (2008) Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor (alpha), tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor. Arthritis & Rheumatism, 58, 2257-2267. doi:10.1002/art.23667
|
[25]
|
Boers, M., Verhoeven, A.C., Markusse, H.M., Vandelaar, M.A.F.J., Westovens, R., Vendenderen, J.C., et al. (1997) Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis. Lancet, 350, 309-318. doi:10.1016/S0140-6736(97)01300-7
|
[26]
|
Singh, D., Smyth, L., Borrill, Z., Sweeney, L. and Tal-Singer, R. (2010) A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients. Journal of Clinical Pharmacology, 50, 94-100.
doi:10.1177/0091270009347873
|
[27]
|
Seideman, P. (1993) Better effect of methotrexate on c-reactive protein during daily compared to weekly treat-ment in rheumatoid arthritis. Clinical Rheumatology, 12, 210-213. doi:10.1007/BF02231528
|
[28]
|
Tukey, J.W., Ciminera, J.L. and Heyse, J.F. (1985) Testing the statistical certainty of a response to increasing doses of a drug. Biometrics, 41, 295-301.
doi:10.2307/2530666
|
[29]
|
Food and Drug Administration (1999) Clinical development programs for drugs devices and biological products for the treatment of Rheumatoid Arthritis (RA). Center for Drug Evaluation and Research (CDER), 1 February 1999.
|
[30]
|
Pasero, G.P. and Di Munno, O. (2002) Analgesic dose range finding of lornoxicam compared to diclofenac. Crossover double blind study in rheumatoid arthritis. Reumatismo, 54, 238-242.
|
[31]
|
Richmond, S.J. (2008) Magnet therapy for the relief of pain and inflammation in rheumatoid arthritis (CAMBRA): A randomized placebo-controlled crossover trial. Trials 9.
|
[32]
|
Van Der Giesen, F.J., Van Lankveld, W.J., Kremers-Selten, C., Peeters, A.J., Stern, E.B., le Cessie, S., et al. (2009) Effectiveness of two finger splints for swan neck deformity in patients with rheumatoid arthritis: A randomized, crossover trial. Arthritis Care & Research, 61, 1025-1031.
doi:10.1002/art.24866
|
[33]
|
Hafstrem, I., Albertsson, K., Boonen, A., Van Der Heijde, D., Landewe, R. and Svensson, B. (2009) Remission achieved after 2 years treatment with low-dose prednisolone in addition to disease-modifying ant-rheumatic drugs in early rheumatoid arthritis is associated with reduced joint destruction still present after 4 years: An open 2-year continuous study. Annals of the Rheumatic Diseases, 68, 508-513. doi:10.1136/ard.2008.087833
|
[34]
|
Irusen, E., Matthews, J.G., Takahashi, A., Barnes, P.J., Chung, K.F. and Adcock, I.M. (2002) p38 Mitogen-acti-vated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: Role in steroid-in-sensitive asthma. Journal of Allergy & Clinical Immunology, 109, 649-657. doi:10.1067/mai.2002.122465
|
[35]
|
Lasa, M., Abraham, S.M., Boucheron, C., Saklatvala, J. and Clark, A.R. (2002) Dexamethasone causes sustained expression of mitogen-activate protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38. Molecular & Cellular Biology, 22, 7802-7811. doi:10.1128/MCB.22.22.7802-7811.2002
|
[36]
|
Toh, M.L., Yang, Y., Leech, M., Santos, L. and Morand, E.F. (2004) Expression of mitogen-activated protein kinase phosphatase 1, a negative regulator of the mitogen-activated protein kinases, in rehmatoid arthritis: Up-regulation by interleukin-1beta and glucocorticoids. Arthritis & Rheumatism, 50, 3118-3128.
doi:10.1002/art.20580
|
[37]
|
Dickson, M.C., Ellis, J., Genqian, C., Wilson, A.G., Bridges, L.S. Jr., Furst, D.E., et al. (2008) Corticosteroid-responsive pharmacodynamic transcriptional markers: Results from a randomized placebo-controlled study of rheumatoid arthritis patients treated with prednisolone. American College of Rheumatology 72nd Meeting. 24 October 2008.
|