New Approach for the Determination of Tricyclic Antidepressant Amitriptyline Using β-Cyclodextrin-PEG System via Spectrophotomerty

Pankaj Soni, Santosh K. Sar, Rajmani Patel

Department of Applied Chemistry, Faculty of Engineering & Technology, Shri Shankaracharya Group of Institutions, Junwani, Bhilai, India.
Department of Engineering Chemistry, Bhilai Institute of Technology, Bhilai House, Durg, India.

DOI: 10.4236/jasmi.2012.22019                

Abstract

A new and simple procedure for the spectrophotometric determination of the tricyclic antidepressant drug amitriptyline is proposed. The method is based on enhancement of sensitivity of the [AMIYTP]+ β-cyclodextrin and PEG molecules involved in formation of molecules inclusion complex, in presence of polyethylene glycol (PEG) medium. The mole ratio of [AMIYTP]+ β-cyclodextrin and PEG molecules in inclusion complex were determined by the curve fitting method. The value of molar absorptivity of {[AMIYTP: (β CD)] PEG} complex in term of the drug lies in rage of (2.20 - 2.23) × 104 L·mole–1·cm–1 at absorption maximum 242 nm. The slope, intercept and correlation co-efficient were found to be 14.21, 0.0046, and 0.998, respectively. The effect of analytical variables on the determination of the drug and composition of the ion associated complex are discussed in the paper. This method is applicable in the determina-tion of amitriptyline in the pharmaceutical preparations.

Keywords

Amitriptyline; PEG; β-Cyclodextrin; Spectrophotometric Determination; AMIYTP-β-Cyclodextrin Complex; Pharmaceuticals

Conflicts of Interest

The authors declare no conflicts of interest.

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