An epidemiological study on delay in treatment initiation of cancer patients

Alok Kumar Dwivedi, Sada Nand Dwivedi, Suryanarayana Deo, Rakesh Shukla, Arvind Pandey, Durgesh Kumar Dwivedi

Center for Biostatistical Services, Division of Biostatistics and Epidemiology, Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, USA.
Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, India.
Department of Surgical Oncology, All India Institute of Medical Sciences, New Delhi, India.
National Institute of Medical Statistics, Indian Council of Medical Research, New Delhi, India.

DOI: 10.4236/health.2012.42012                

Abstract

Early diagnosis and timely initiation of treatment of cancer patients may improve survival and quality of life. Various measures of delay can be made during diagnosis and treatment initiation. Most of the studies were based on single type of cancer with different definitions and measurements of delay in diagnosis and treatment. Thus, it has been difficult to synthesize results and generalize to other types of cancer. The study proposes to measure total duration between onsets of symptom to start of treatment into three components, namely primary, secondary and tertiary delays. Primary delay is defined as onset of symptoms to contacting the first medical person, secondary delay is from first medical contact to confirmed diagnosis, and tertiary delay is from confirmed diagnosis to treatment initiation. The aim of this study is to determine factors associated with primary, secondary and tertiary delays in cancer patients. This study was planned as a cross-sectional study. Data was collected from patients admitted to the surgical wards of Department of Surgical Oncology, Institute Rotary Cancer Hospital, New Delhi during 2006-2007. Gamma regression and quantile regressions at 25th, 50th and 75th percentile of each of the delays were used to determine related factors. A total of 403 patients were included in the analysis. The median tertiary delay was found almost two folds (59; Interquartile range: 26 - 101 days) than the primary and secondary delays. Extremity cancer patients had longest primary, secondary and tertiary delays. Shortest primary, secondary and tertiary delays were observed for gastrointestinal cancer, breast and genitourinary cancer respectively. There is an urgent need and scope to reduce delay at each level primary, secondary and tertiary delay. Intervention studies are needed through information, education and communication/screening programs to reduce the diagnostic and treatment delays in cancer patients.

Keywords

Delay; Cancer; Log Gamma Regression; Quantile Regression

Conflicts of Interest

The authors declare no conflicts of interest.

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