Metastatic Soft Tissue Tumors

Tomoaki Torigoe, Atsuhiko Terakado, Yoshiyuki Suehara, Taketo Okubo, Tatsuya Takagi, Kazuo Kaneko, Yasuo Yazawa

.

DOI: 10.4236/jct.2011.25100                

Abstract

Between 1998 and 2007, we treated 157 patients with malignant soft tissue tumors. Patients with obvious lymph node metastasis, metastasis from bone or soft tissue sarcoma, and with obvious advanced stage disease which had multiple metastases were excluded from the present analysis. Finally, sixteen of the 157 patients were diagnosed to have soft tissue metastasis from carcinomas or hematopoietic malignancies. There were 10 males and 6 females with an average age of 65 (range, 50 - 83) years. Four lesions were located in the abdomen and back, 3 in the thigh, 2 in the chest, and 1 lesion each in the upper arm, lower leg and buttock. There were 9 intramuscular and 7 subcutaneous metastases. The average tumor size was 6 cm (range 2 - 17 cm). The initial diagnoses were a primary soft tissue tumor in 8 cases, primary soft tissue tumor or metastatic soft tissue tumor in 6, and inflammatory lesions in 2. Four of the 6 cases were suspected to be a metastatic soft tissue tumor in the initial diagnosis based on a past history of malignancy. There were no characteristic findings of metastatic soft tissue tumors in the imaging studies. The primary origins were lung cancer in 6 cases, malignant lymphoma in 5, gastric cancer in 2, and esophageal cancer, pancreatic cancer and uterine cancer in 1 patient each. Treatments were administered to all cases, including radiotherapy and chemotherapy in 11, chemotherapy in 2, wide resection and chemotherapy in 1, radiotherapy in 1 and palliative therapy in 1. The final oncological status was continuous disease free survival in 1 patient, no evidence of disease in 1, alive with disease in 7, and dead of disease in 7 patients. The estimated one-year survival was 47% and the two-year survival was 0%.

Keywords

Soft Tissue Tumor, Metastasis, Carcinoma, Lymphoma, Inflammation

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	K. S. Sridhar, R. K. Rao and B. Kunhardt, “Skeletal Muscle Metastases from Lung Cancer,” Cancer, Vol. 59, No. 8, 1987, pp. 1530-1534. doi:10.1002/1097-0142(19870415)59:8<1530::AID-CNCR2820590824>3.0.CO;2-H
[2]	P. P. McKeown, P. Conant and L. E. Auerbach, “Squamous Cell Carcinoma of the Lung: An Unusual Metastasis to Pectoralis Muscle,” The Annals of Thoracic Surgery, Vol. 61, No. 5, 1996, pp. 1525-1526. doi:10.1016/0003-4975(95)01177-3
[3]	R. A. Willis, “The Spread of Tumours in the Human Body,” Butterworth and Co., London, 1952.
[4]	C. M. Pearson, “Incidence and Type of Pathologic Alterations Observed in Muscle in a Routine Autopsy Survey,” Neurology, Vol. 9, 1959, pp. 757-766.
[5]	Y. Tuoheti, K. Okada, T. Osanai, J. Nishida, S. Ehara, M. Hashimoto and E. Itoi, “Skeletal Muscle Metastases of Carcinoma: A Clinicopathological Study of 12 Cases,” Japanese Journal of Clinical Oncology, Vol. 34, No. 3, 2004, pp. 210-214. doi:10.1093/jjco/hyh036
[6]	A. Sudo, Y. Ogihara, Y. Shiokawa, S. Fujinami and S. Sekiguchi, “Intramuscular Metastasis of Carcinoma,” Clinical Orthopaedics and Related Research, Vol. 296, 1993, pp. 213-217
[7]	T. A. Damron and J. Heiner, “Distant Soft Tissue Metastases: A Series of 30 New Patients and 91 Cases from the Literature,” Annals of Surgical Oncology, Vol. 7, No. 7, 2000, pp. 526-534. doi:10.1007/s10434-000-0526-7
[8]	J. A. Plaza, D. Perez-Montiel, J. Mayerson, C. Morrison and S. Suster, “Metastases to Soft Tissue: A Review of 118 Cases over a 30-Year Period,” Cancer, Vol.112, No. 1, 2008, pp. 193-203. doi:10.1002/cncr.23151
[9]	T. A. Damron and J. Heiner, “Management of Metastatic Disease to Soft Tissue,” Orthopedic Clinics of North America, Vol. 31, No. 4, 2000, pp. 661-673. doi:10.1016/S0030-5898(05)70183-8
[10]	S. Masaoka and T. Fu, “Malignant Lymphoma in Skeletal Muscle with rhabdomyolysis: A Report of Two Cases,” Journal of Orthopaedic Science, Vol. 7, No. 6, 2002, pp. 688-693. doi:10.1007/s007760200122
[11]	J. B. Williams, R. A. Youngberg, L. T. Bui-Mansfield and J. D. Pitcher, “MR Imaging of Skeletal Muscle Metastases,” American Journal of Roentgenology, Vol. 168, No. 2, 1997, pp. 555-557.
[12]	G. R. Avery, “Metastatic Adenocarcinoma Masquerading as a Psoas Abscess,” Clinical Radiology, Vol. 39, No. 3, 1988, pp. 319-320. doi:10.1016/S0009-9260(88)80554-3