Amine solution foaming is affected by many factors, effectively predicting and analyzing the foaming of amine solution, which is of great significance to the smooth operation of the plant and the improvement of product gas quality. Based on the production data of Puguang gas field, the author predicted the foaming condition of amine solution by establishing the mathematical model of GM(1,1). The results show that the method is simple and the prediction accuracy is relatively high, which can meet the actual production needs.