Author(s)

Serges Magloire Camengo Police^1*, Georges Service², Nathalie Philomène Boua-Akelelo¹, Diane N’guilé¹, Benoît Elowa¹, Timothée Mobima³, Francky Kouandogui Bangué⁴, Eveline Mofini¹, Yangba Kalebanga Armelo Thibaut¹, Bessanguem Bernard¹, Boniface Koffi⁵

¹Department of Hepatogastroenterology and Internal Medicine of “Amitié Sino-Centrafraine” University Hospital Center, Bangui, Central African Republic.
²Department of Internal Medicine “Maman Elisabeth Domitien” University Hospital Center, Bimbo, Central African Republic.
³Department of Radioloy and Medical Imaging of “Amitié Sino-Centrafraine” University Hospital Center, Bangui, Central African Republic.
⁴Department of Radioloy and Medical Imaging of “Maman Elisabeth Domitien” University Hospital Center, Bimbo, Central African Republic.
⁵Department Pathological Anatomy National Laboratory of Clinical Body and Public Health, Bangui, Central African Republic.

Objective: To describe the epidemiological, clinical, biological and morphological aspects of primary liver cancer (PLC). Patients and Methods: We conducted a 38-month cross-sectional study in the Department of hepatogas-troenterology and Internal Medicine “Amitié Sino-Centrafraine” University Hospital Center in Bangui. Included in the study were all patients with a diagnosis of PLC. The PLC’s diagnostic arguments were the large tumor liver associated or not with the elevation of alpha-fetoprotein, the heteronodular liver hypervascularized on abdominal ultrasound. Data analysis was done using Epi Info 3.5.1 software. Results: We collected 115 cases of CPF among 2410 hospitalized patients (4.7%). There were 86 men and 29 women (sex ratio: 2.9). The average age was 50 years old. The main risk factors were alcohol consumption (72.2%) and chronic hepatitis B infection (67.4%). Frequent clinical signs were pain in the right hypochondrium and/or epigastric (93.86%), large tumor liver under examination (91.3%), weight loss (74.78%). The serum alpha-fetoprotein concentration was ≥ 400 ng/ml in 73% of the cases. The abdominal ultrasound found a heteronodular liver in all patients. The nodules were multiple hyperechoic in 66.1% of the cases. According to the Child-Pugh classification, the patients were classified as B (49.5%) and C (33.9%). The Okuda Classification ranked patients at stage 1 in 16.5% cases, stage 2 in 52.1% cases and stage 3 in 31.3% cases. According to the BCLC classification, 5.2% of patients were in stage A, 12.2% in stage B, 52.2 in stage C and 30.4% in stage D. Death was recorded during hospitalization in 89 cases (77.4%). Conclusion: CPF is a frequent and serious pathology in Bangui. Its diagnosis is often late, preventing curative treatment. The main causes are alcohol consumption and the hepatitis B virus. The population should be educated to reduce the incidence of this disease.

Primary Liver Cancer, Epidemiology, Clinical, Morphology, Bangui

Camengo Police, S. , Service, G. , Philomène Boua-Akelelo, N. , N’guilé, D. , Elowa, B. , Mobima, T. , Bangué, F. , Mofini, E. , Armelo Thibaut, Y. , Bernard, B. and Koffi, B. (2020) The Epidemiological, Clinical, Biological and Morphological Characteristics of Primitive Liver Cancers in Bangui. Open Journal of Gastroenterology, 10, 97-105. doi: 10.4236/ojgas.2020.104010.