Author(s)

Kingsley Kalawari Odiabara¹, Edna Ogechi Nwachuku¹, Ndokiari Boisa², Ebirien-Agana Samuel Bartimaeus¹

¹Department of Medical Laboratory Science, Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Nigeria.
²Department of Chemistry, Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Nigeria.

Introduction: Infectious agents such as hepatitis B virus can constitute major public health problems as ii affects the liver resulting into inflammatory conditions. This study was designed to assess plasma lipid profile and atherogenic indexes of hepatitis B virus carriers among voluntary blood donors in North Central, North East and South-South regions of Nigeria. Materials & Methods: A total of 183 blood samples were collected from subjects in North Central consisting of 137 males and 46 females; 176 blood samples from the North East consisting of 129 males and 47 females and 173 blood samples from subjects in South-South region consisting of 123 males and 50 females. The mean ages of the subjects were 34.89 ± 9.19 years, 39.81 ± 9.60 years and 39.92 ± 9.27 years for North Central, North East and South-South regions respectively. The specimens were tested for hepatitis B surface antigen using enzyme-linked immunosorbent assay. All specimens were analyzed for total cholesterol, HDL-C, LDL-C and triglycerides with standard biochemical procedures. The atherogenic indexes were computed using established ratios. The data was analyzed statistically and p-value < 0.05 was considered significant. Results: The mean values of total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, and triglycerides did not vary significantly (p > 0.05) between the hepatitis B positive carriers and hepatitis B negative subjects across the geo-political zones studied although in some of the parameters the values were on the high normal range between the male and female subjects. The AIP and CRR-1 and CRR-11 of the blood donors in the zones in both the HBsAg positive and negative subjects were within the reference range. The atherogenic coefficient value of >3.0 was obtained for some HBsAg negative and positive subjects in some of the zones. Conclusion: The findings thus indicate that asymptomatic HBV infection may be associated with low risk of dyslipidaemia in the population.

Hepatitis, Atherogenic Indices, Lipoproteins, Cardiovascular Disease, Blood Donors

Odiabara, K. , Nwachuku, E. , Boisa, N. and Bartimaeus, E. (2020) Assessment of Lipid Profile and Atherogenic Indexes of Hepatitis B Virus Carriers amongst Volunteer Blood Donors in Nigeria. Journal of Biosciences and Medicines, 8, 81-95. doi: 10.4236/jbm.2020.84007.