Thanks to its performance in eliminating color, UV absorbance, trace organic compounds, and microorganisms, ozone application in treating water has acquired vogue. The intensification of mass transfer and mixing in ozone-founded disinfection methods stays so crucial to attaining the desired disinfection level at an acceptable price. This work discusses the growing tendency of improving ozone diffusion for better water disinfection. Researchers suggested a new procedure of ozonation supported by a liquid whistle reactor (LWR), which produces hydrodynamic cavitation, for disinfecting water. This integration has been observed to be a cost-efficient method for attaining extreme disinfection paralleled to the solo running of hydrodynamic cavitation (lower magnitude of disinfection) and ozonation (higher prices of treatment frequently attributed to higher cost of ozone production). Further, juxtaposed to the traditional bubble reactor, the achievement of high disinfection performance at a small Ct estimate in a rotating packed bed (RPB) depicted that RPB is an efficacious ozone disinfection contactor for killing microorganisms in water. Finally, electrogenerated ozonation could be a surpassed technique confronted with chlorination in terms of disinfection and poisoning reduction.