Author(s)

Luis Álvarez-Santamaría¹, Eusebio Juaristi^2,3, Alexa Berenice Arroyo-Colín¹, Jorge Palma-Flores¹, Fanny Araceli Cabrera-Rivera¹, Jaime Escalante^1*

¹Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico.
²Departamento de Química, Centro de Investigación y de Estudios Avanzados, Ciudad de México, México.
³El Colegio Nacional, Luis Gonzáles Obregón 23, Centro Histórico, Ciudad de México, México.

A simple one-pot procedure for the preparation of imines from the corresponding aldehydes and amines, and their subsequent oxidation reaction with m-CPBA to produce synthetically useful oxaziridines is reported. The method is applicable to imines derived from both aliphatic and aromatic aldehydes and diverse alkyl amines. Short reaction times, essentially quantitative yields, very mild reaction conditions, and easy purification are the main features of the procedure reported herein.

Solvent-Free Reaction, Imines, Oxaziridines, Oxidation Reaction, m-CPBA

Álvarez-Santamaría, L. , Juaristi, E. , Arroyo-Colín, A. , Palma-Flores, J. , Cabrera-Rivera, F. and Escalante, J. (2019) Efficient Solvent-Free Preparation of Imines, and Their Subsequent Oxidation with m-CPBA to Afford Oxaziridines. Green and Sustainable Chemistry, 9, 143-154. doi: 10.4236/gsc.2019.94011.