Differences in the Receptor Binding Profile of Lofexidine Compared to Clonidine - Pharmacology & Pharmacy

PP > Vol.10 No.1, January 2019

Pharmacology & Pharmacy

Volume 10, Issue 1 (January 2019)

ISSN Print: 2157-9423 ISSN Online: 2157-9431

Google-based Impact Factor: 0.70 Citations h5-index & Ranking

Differences in the Receptor Binding Profile of Lofexidine Compared to Clonidine ()

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DOI: 10.4236/pp.2019.101001 1,518 Downloads 2,472 Views Citations

Author(s)

Robert B. Raffa^1,2,3, Joseph V. Pergolizzi^1,4, Robert Taylor⁴, Robert P. James⁵, Mark Pirner⁵

Affiliation(s)

¹Neumentum, Inc., Palo Alto, CA, USA.
²University of Arizona College of Pharmacy, Tucson, AZ, USA.
³Temple University School of Pharmacy, Philadelphia, PA, USA.
⁴NEMA Research, Inc., Naples, FL, USA.
⁵US WorldMeds, LLC, Louisville, KY, USAs.

ABSTRACT

Lucemyra? (lofexidine hydrochloride) has recently been approved by the US FDA for the mitigation of withdrawal symptoms to facilitate abrupt discontinuation of opioids in adults. Lofexidine is an alpha-2 adrenoceptor agonist. However, the clinical attributes of lofexidine differ in advantageous ways from the classical alpha-2 adrenoceptor agonist clonidine. In the present study, we measured the receptor binding profile of lofexidine and clonidine in an effort to gain an insight into the clinical difference(s).

KEYWORDS

Lofexidine, Clonidine, Opioid Withdrawal, Receptor Affinity, Alpha-2 Agonist

Share and Cite:

Raffa, R. , Pergolizzi, J. , Taylor, R. , James, R. and Pirner, M. (2019) Differences in the Receptor Binding Profile of Lofexidine Compared to Clonidine. Pharmacology & Pharmacy, 10, 1-10. doi: 10.4236/pp.2019.101001.

Cited by

[1]	Managing Opioid Withdrawal in an Outpatient Setting With Lofexidine or Clonidine
	Cureus, 2022

[2]	Efficacy of lofexidine for mitigating opioid withdrawal symptoms: results from two randomized, placebo-controlled trials
	2020

[3]	Effect of lofexidine on cardiac repolarization during treatment of opioid withdrawal
	2019

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