Author(s)

Ahmed H. Abd-Ellah¹, Abd El-Naser Abd El-Gaber Ali^1*, Mustafa M. Khodry¹, Mahmoud I. El-Rasheedy², Ahmed M. Abbas³

¹ART Unit, Department of Obstetrics & Gynecology, Faculty of Medicine, South Valley University, Qena, Egypt.
²Department of Obstetrics & Gynecology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
³Department of Obstetrics & Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt.

OBJECTIVE: To assess the effect of vitamin D supplementation on enhancement of embryos implantation rates in intracytoplasmic sperm injection procedures. STUDY DESIGN: A randomized double-blinded controlled trial. SETTING: Assisted Reproduction Unit of Obstetrics and Gynecology Department, Faculty of Medicine, South Valley University, Egypt. DURATION: From December 1^st 2017 to the end of October 2018. SUBJECTS and METHDS: Eighty infertile couples that underwent ICSI procedure were entrapped in this study. Patients were divided into two groups; Group I (Vitamin D group) = 40 patients (received vitamin D supplementation in the form of Vidrop oral drops 600 IU/day starting after ovum pickup) and Group II (placebo group) = 40 patients (received a placebo “normal saline oral drop”). RESULTS: There was a significantly increased embryo implantation rates (53.2% in vitamin D group versus 46.7% in placebo group), there was a mild statistically significant difference in the clinical pregnancy rates (45.9% in vitamin D group versus 39.4% in placebo group) with p-value < 0.05 and there was an improvement in ongoing pregnancy rate as there was a mild statistically significant difference in first trimester miscarriage rates (12.5% in vitamin D group versus 17.5% in placebo group) with p value < 0.05 CONCLUSIONS: Vitamin D supplementation could improve embryos implantation rates and rate of ongoing pregnancy by decline in the first trimester miscarriage rate.

Vitamin D, Intracytoplasmic Sperm Injection, ICSI

Abd-Ellah, A. , Ali, A. , Khodry, M. , El-Rasheedy, M. and Abbas, A. (2018) Effect of Vitamin D Supplementation on Intracytoplasmic Sperm Injection Outcomes: A Randomized Double-Blinded Placebo-Controlled Trial. Open Journal of Obstetrics and Gynecology, 8, 1549-1556. doi: 10.4236/ojog.2018.814155.