Author(s)

Heinz Langhals^*, Oswald Krotz

Department of Chemistry, LMU University of Munich, Munich, Germany.

Deviations from chemical parity (PV) were evaluated with the search for very small enantiomeric excesses in a racemate prepared from non chiral materials and were detected by means of the circular dichroism (CD). Thus, intensely light-absorbing perylenebiscarboximides were attached to axially chiral biphenyls for the amplification of CD effects by exciton interactions of the adjacent chromophores. A rapidly racemising system was applied for the exclusion of artifacts and compared with an analogous with locked chirally. A very slight enantiomeric excess was detected for the (M) enantiomer. Application of the method for other systems was suggested and relations to natural products discussed.

Chirality, Parity, Circular Dichroism, UV/Vis Spectroscopy, Racemates

Langhals, H. and Krotz, O. (2018) A Concept for a Novel Test for Chemical Parity. Green and Sustainable Chemistry, 8, 311-319. doi: 10.4236/gsc.2018.84021.