Author(s)

Kazuto Doi^1,2, Mitsuhiro Nishitani³, Mayumi Doi⁴, Yukoh Yaegashi⁵, Masaru Ando⁶, Junichi Kadota⁶

¹Department of Pathophysiology, Faculty of Medicine, Oita University, Oita, Japan.
²Department of Medical Engineering, Faculty of Allied Health Sciences, University of East Asia, Yamaguchi, Japan.
³Daimon Clinic for Internal Medicine, Nephrology and Dialysis, Ishikawa, Japan.
⁴Department of Clinical Pharmacology & Therapeutics, Faculty of Medicine, Oita University, Oita, Japan.
⁵Department of Medical Engineering, Faculty of Health Sciences, Junshin Gakuen University, Fukuoka, Japan.
⁶Department of Respiratory Medicine & Infectious Diseases, Faculty of Medicine, Oita University, Oita, Japan.

Introduction: During the application of non-invasive positive pressure ventilation (NPPV) therapy in home mechanical ventilation (HMV), leaks in the NPPV mask may occur owing to the position of the mask due to conditions such as skin disorders. Methods: To investigate whether such a leak affects FiO₂ supplied to the alveoli, we simulated a patient with chronic obstructive pulmonary disorder during NPPV in HMV. In addition, FiO₂ was measured in the portion assumed to be the mouth and lungs while setting the flow of the oxygen concentrator and leak amount based on a previous study. Results: FiO₂ supplied to the lungs increased statistically significantly upon increasing the amount of leak (P < 0.001). Moreover, values measured for the mouth were similar. However, our results were different from those of a previous study. Conclusions: We observed that FiO₂ supplied to alveoli can be reduced by a leak in the NPPV mask. Because our results differ from those previously reported, we believe that further studies should reassess the selection of respirators and oxygen concentrators.

Mask, Oxygen, Ventilation, Positive-Pressure Ventilation, Chronic Obstructive Pulmonary Disorder

Doi, K. , Nishitani, M. , Doi, M. , Yaegashi, Y. , Ando, M. and Kadota, J. (2018) Influence of Leakage from Non-Invasive Positive Pressure Ventilation Mask on FiO₂ Value Delivered by Home Oxygen Therapy Concentrator: A Bench Study on Simulating Patients with Chronic Obstructive Pulmonary Disease. Health, 10, 919-927. doi: 10.4236/health.2018.107068.