Bile Acid Effects on Placental Damage in Intrahepatic Cholestasis of Pregnancy ()
ABSTRACT
Aims: The abnormal increase of bile acid is found in intrahepatic cholestasis
of pregnancy (ICP). It also can be observed the damage of placental tissue in
ICP. The aim of this study was to find the associations of the bile acid in
umbilical vein and the damage of placental tissue. Methods: Thirty women
diagnosed with ICP and fifty normal pregnant women between September 2015 and
September 2017 at Nanshan District Maternity & Child Healthcare Hospital of
Shenzhen were included in this study. The glycocholic acid (GA), total bile
acids (TBA), total bilirubin (TB),
direct bilirubin (DB)
and albumin level in umbilical vein were measured by cycle enzyme method in ICP
and control group. The placental damage was analyzed by morphologic study using
hematoxylin dyes in two groups. The correlation between the level of the bile
acid in the umbilical vein and the damage of the placenta was assessed using
SPSS software. Results: The GA, TBA, TB, DB and albumin level in
umbilical vein were significantly higher in ICP than those of pregnant women,
respectively. The placental villis were expanded and the structure was
destroyed in ICP. The vessel was damaged and the cell trophoblast hyperplasia
in ICP. It also can be seen that there was obvious nodules and a typical
fibrous necrotic substance in ICP but not in control group. There is a positive
correlation between the level of the TBA in the umbilical vein and the damage
of the placenta in ICP. Conclusion: The TBAs were significantly higher
in umbilical vein and were related to the placental damage in ICP.
Share and Cite:
Xie, F. , Liu, X. , Xiao, P. , Huang, Y. , Chen, Q. and Zhou, L. (2018) Bile Acid Effects on Placental Damage in Intrahepatic Cholestasis of Pregnancy.
Journal of Biosciences and Medicines,
6, 42-52. doi:
10.4236/jbm.2018.66003.