ABSTRACT
Influence of distinct
radiotherapy techniques to induce second cancer risks in left breast cancer. Material
and methods: Ten female patients with intact left breast cancer. Two treatment plans for
each patient: 1) two tangential beams
3D-Conformal radiotherapy, 2) intensity-modulated radiotherapy (IMRT) plan. Estimation of second cancer risk
from Organ equivalent dose models (OEDs) in three dose-response model for
organs at risk in left breast cases. Results: The P-value for OED models in
3D-IMRT for left lung, both lung, heart, right lung, right breast, thyroid,
liver and spinal cord in linear dose model was 0.016, 0.005, 0.019, 3.95E-06, 5.79E-07, 0.003, 1.78E-10 and 0.000206475
respectively, for linear exponential dose model 0.0577, 0.024, 0.031, 3.40E-06, 3.28E-07, 0.003, 2.01E-10 and 0.000120072
respectively and in plateau dose model 0.088, 0.042, 0.039, 3.18E-06, 2.53E-07, 0.003, 2.27E-10 and 9.00535E-05 respectively.
Conclusion: organ equivalent dose models for organs at risk increasing in IMRT
than tangential beams.