Author(s)

Niknam Zahra¹, Saadat Alireza², Nabavi Seyed-Massood³, Morsali Damineh⁴, Hatami-Sadabadi Farhad⁵, Kheirkhahan Meghdad⁵, Mehdipour Baharak^5*

¹Neurologist, Neurology Department, University of Baghiatalahaazam, Tehran, Iran.
²University of Baghiatalahaazam, Tehran, Iran.
³Department of Regenerative Biomedicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
⁴Senior postdoctoral fellow, Neurology department, Texas University, Huston, Texas, USA.
⁵General physician, Kheradmand Clinical Research Center, Medical Affairs Division, Actoverco Pharmaceutical Company, Tehran, Iran.

Introduction: Stroke is the second major cause of mortality worldwide and in several cases, and it may lead to disability. Factor V Leiden is a common genetic thrombophilia, which causes activated protein C (APC) resistance. Hyperhomocysteinemia and factor V Leiden deficiency, two independent coagulopathy factors, can lead to venous and arterial infarctions in multiple small and large arteries and veins anywhere in the body. Case Report: Here, we report a unique case in which both hyperhomocysteinemia and factor V Leiden deficiency are documented together with MTHFR (C677T) (Methylene Tetra Hydro Folate Reductase) gene polymorphism and activated protein C resistance respectively. Conclusion: More interestingly, the mode of presentation in this case highly resembled that of progressive multiple sclerosis; all signs and symptoms slowly progressed without any systemic signs at first few years. Further studies needed to assess current outcomes.

Hyperhomocysteinemia, Thrombophilia V, MTHFR (C677T) Gene Polymorphism, Activated Protein C Resistance, Multiple Sclerosis

Zahra, N. , Alireza, S. , Seyed-Massood, N. , Damineh, M. , Farhad, H. , Meghdad, K. and Baharak, M. (2017) Stroke Due to Hypercoagulable State Can Mimic Multiple Sclerosis: A Case Report. World Journal of Neuroscience, 7, 267-274. doi: 10.4236/wjns.2017.73022.