International Journal of Clinical Medicine

Volume 2, Issue 4 (September 2011)

ISSN Print: 2158-284X   ISSN Online: 2158-2882

Google-based Impact Factor: 0.52  Citations  h5-index & Ranking

Vasoactive Intestinal Peptide (VIP) and VIP Receptors-Elucidation of Structure and Function for Therapeutic Applications

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DOI: 10.4236/ijcm.2011.24084    8,294 Downloads   14,114 Views  Citations

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ABSTRACT

Vasoactive intestinal peptide (VIP) is a 28-amino acid polypeptide first isolated from swine duodenum. VIP is a neurotransmitter that is extensively distributed in tissues. According to published reports, VPAC1 and VPAC2 act as VIP receptors and are widely present in the central nervous system and peripheral tissues. VIP exerts diverse actions on the cardiovascular system, pancreas, digestive tract, respiratory system, and urological system. Recent reports indicated that VIP has immunological and neuroprotective effects and also affects cell growth. While primary investigations for developing therapeutic applications for various pathological conditions and diseases are underway, the structure and function of VIP should be analyzed in more detail.

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H. Igarashi, N. Fujimori, T. Ito, T. Nakamura, T. Oono, K. Nakamura, K. Suzuki, R. Jensen and R. Takayanagi, "Vasoactive Intestinal Peptide (VIP) and VIP Receptors-Elucidation of Structure and Function for Therapeutic Applications," International Journal of Clinical Medicine, Vol. 2 No. 4, 2011, pp. 500-508. doi: 10.4236/ijcm.2011.24084.

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