Open Journal of Inorganic Chemistry

Volume 7, Issue 2 (April 2017)

ISSN Print: 2161-7406   ISSN Online: 2161-7414

Google-based Impact Factor: 1.08  Citations  

Hydrothermal Synthesis and Characterization of Copper Glycinate (Bio-MOF-29) and Its in Vitro Drugs Adsorption Studies

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DOI: 10.4236/ojic.2017.72002    1,696 Downloads   2,835 Views  Citations

ABSTRACT

A new porous compound, Copper glycinate (Bio-MOF-29), [Cu(C2H4NO2)2 (H2O)] has been synthesized by the hydrothermal method and characterized by single crystal XRD analysis. Bio-MOF-29 crystallized in orthorhombic crystal system with P212121 space group. In vitro adsorption studies of four different drugs, terazosine hydrochloride, telmisartan, glimpiride and rosuvastatin have been carried out for Bio-MOF-29. Drugs adsorption estimations of drugs loaded Bio-MOF-29 have been carried out through High Performance Liquid Chromatography (HPLC), which reveals that these drugs are successfuly adsorbed in it. Also the slow release of adsorbed drugs after intervals was observed through HPLC. Thermograms and powder XRD patterns of Bio-MOF-29 before and after drugs adsorption were also recorded to elaborate the phenomenon of drugs adsorption in Bio-MOF-29.

Share and Cite:

Sattar, T. and Athar, M. (2017) Hydrothermal Synthesis and Characterization of Copper Glycinate (Bio-MOF-29) and Its in Vitro Drugs Adsorption Studies. Open Journal of Inorganic Chemistry, 7, 17-27. doi: 10.4236/ojic.2017.72002.

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