Author(s)

Nausheen Jamal¹, Yuichiro Kezuka², Takamasa Nonaka², Kazuaki Ohashi¹, Koji Nata¹

¹Department of Medical Biochemistry, School of Pharmacy, Iwate Medical University, Yahaba, Japan.
²Department of Structural Biology, School of Pharmacy, Iwate Medical University, Yahaba, Japan.

Staphylococcus aureus is pathogenic to humans with worldwide health care concern due to its ability to evade the immune system and develop resistance to multiple drugs. Reg family proteins are C-type lectins with antimicrobial properties. Bacterial aggregation through binding to microbial cell surface sugar and/or lipid moieties is key mechanism employed in the process. In the present study we have analysed the antimicrobial effect of human REG Iα on S. aureus. Aggregation of mid-log phase culture of S. aureus was observed in presence of purified recombinant REG Iα. Therefore REG Iα can be applied in eliminating S. aureus infections in humans.

Reg Proteins, Lectin-Like Activity, Bacterial Aggregation

Jamal, N. , Kezuka, Y. , Nonaka, T. , Ohashi, K. and Nata, K. (2017) Recombinant Human REG Iα Aggregates Staphylococcus aureus—Exhibits a Lectin-Like Function. Advances in Bioscience and Biotechnology, 8, 79-90. doi: 10.4236/abb.2017.83006.