Bronchopulmonary Dysplasia in Premature Infants with Very Low Birth Weight: A Single Centre Retrospective Study in China ()
ABSTRACT
To investigate bronchopulmonary dysplasia (BPD) and
its treatment with dexamethasone (DEX) in premature infants with birth weight
(BW) < 1500 g. We retrospectively reviewed the records of preterm infants
admitted to the Division of Neonatology, the Second Xiangya Hospital, Central
South University between September 2011 and December 2014. Patients were
excluded if they needed oxygen therapy but were lost to follow-up at ≤36 weeks
post-menstrual age (PMA) or <56 days after birth, or they had severe
congenital anomalies. The incidence of BPD was 18% (37/212). Gestational age
(GA) was <32 weeks in all BPD patients. GA, BW, and Apgar scores were lower
and hospitalization duration and pulmonary surfactant (PS) use were higher in
the BPD group than in the non-BPD group (P < 0.05). Risk factors for BPD included neonatal respiratory distress
syndrome, neonatal pneumonia, positive sputum culture, pulmonary hemorrhage,
respiratory failure. Multivariate logistic regression revealed that GA (odds
ratio [OR]: 0.479, P = 0.004) and
neonatal respiratory distress syndrome (OR: 6.146, P = 0.043) were independent risk factors for BPD. DEX was administered
to 26 patients after the diagnosis of BPD. After one and two weeks of DEX
treatment, the oxygen requirement had significantly reduced compared to the
week prior to treatment (P < 0.05),
while during treatment, the weight gain rate and weight gain efficiency slower significantly
than that during either of the two preceding weeks (P < 0.001). These results suggest that low GA was the most
important risk factor for BPD, DEX reduced oxygen dependency but decreased
weight gain.
Share and Cite:
Shen, L. , Bo, T. , Luo, S. , Zhang, R. and Li, J. (2016) Bronchopulmonary Dysplasia in Premature Infants with Very Low Birth Weight: A Single Centre Retrospective Study in China.
Open Journal of Pediatrics,
6, 295-307. doi:
10.4236/ojped.2016.64041.
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