Author(s)

Masaaki Minami^1*, Naoki Wakiyama², Minoru Ohhashi², Yukio Wakimoto², Michio Ohta³

¹Department of Bacteriology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.
²Department of Clinical Investigation, Nagoya City University Hospital, Nagoya, Japan.
³School of Nursing, Sugiyama Jyogakuen University, Nagoya, Japan.

Escherichia coli infection is important cause of morbidity and mortality. Urosepsis is most commonly caused by Escherichia coli. It is generally reported to have low mortality rates and favorable outcomes compared with sepsis induced in other organ/ system or tissues. This study was conducted to find out the clinical characteristics of urosepsis-associated Escherichia coli isolates at tertiary care university hospital in the central region of Japan from 2008 to 2011. Escherichia coli was identified by standard laboratory procedure. Antimicrobial susceptibility testing was performed by micro dilution assay according to CLSI recommendation. We analyzed the relationship between medical records appended to clinical species and bacterial data by using a statistical method. Of one hundred five Escherichia coli, fifty-three were from urosepsis and fifty-two were from other disease. The ratio of male to female from urosepsis tended to be lower than that from others. Forty-two isolates were from outpatient and sixty-three were from inpatient. The ratio of inpatient to outpatient from urosepsis was significant lower than that from others. With respect to age, the numbers of elder patients were higher than those of others. Most of the Escherichia coli isolates were from the emergency room followed by urology, and general medicine. The ratio of urosepsis to no urosepsis at urology department was significant higher than that at other departments. With respect to antimicrobial susceptible pattern, the ratio of urosepsis to no urosepsis about only aztreonam resistant was significant higher than that about other antibiotics. We need enough attention to be paid to urosepsis, especially female and elder patients.

Escherichia coli, Urosepsis, Antimicrobial Resistance Susceptibility, Epidemiology

Minami, M. , Wakiyama, N. , Ohhashi, M. , Wakimoto, Y. and Ohta, M. (2016) Comparative Study of Urosepsis-Associated Escherichia coli in Tertiary Care University Hospital in the Central Region of Japan from 2008 to 2011. Journal of Biosciences and Medicines, 4, 18-23. doi: 10.4236/jbm.2016.411003.