Immune Augmentation of Injectable PLGA – Dextran (PLDEX) a Double Polymeric Microspheres as an Adjuvant for Hepatitis B Vaccine - World Journal of Vaccines

WJV > Vol.1 No.3, August 2011

Volume 1, Issue 3 (August 2011)

ISSN Print: 2160-5815 ISSN Online: 2160-5823

Google-based Impact Factor: 0.86 Citations

Immune Augmentation of Injectable PLGA – Dextran (PLDEX) a Double Polymeric Microspheres as an Adjuvant for Hepatitis B Vaccine ()

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DOI: 10.4236/wjv.2011.13011 4,168 Downloads 8,293 Views Citations

Author(s)

Sivakumar Sivagurunathan Moni, Sukumaran Natarajapillai, Mohammed M. Safhi

Affiliation(s)

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Department of Pharmaceutical Microbiology, College of Pharmacy, Jazan University, Jazan, Kingdom of Saudi Arabia.

ABSTRACT

A new method has been developed to prepare microspheres by blending PLGA and dextran polymers (PLDEX) using solvent evaporation technique. Recombinant hepatitis B vaccine (HBsAg) was incorporated in to the double polymeric system. The objective of this study was to investigate the feasibility of PLDEX polymeric microspheres as an adjuvant for hepatitis B vaccine (HBsAg). The present study demonstrates the immunogenicity profile of HBsAg encapsulated in PLDEX and compared their efficacy with alum adsorbed HBsAg. The single intramuscular injection of HBsAg loaded PLDEX microspheres in Wistar rats resulted satisfactory antibody titers. Based on in vivo findings PLDEX microspheres were able induce satisfactory immune response.

KEYWORDS

HBsAg; PLGA – Dextran Microspheres; Vaccine Delivery; Immunogenicity

Share and Cite:

S. Moni, S. Natarajapillai and M. Safhi, "Immune Augmentation of Injectable PLGA – Dextran (PLDEX) a Double Polymeric Microspheres as an Adjuvant for Hepatitis B Vaccine," World Journal of Vaccines, Vol. 1 No. 3, 2011, pp. 104-108. doi: 10.4236/wjv.2011.13011.

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