Evaluation of Antalgic Activity and Trace Elements Analysis of Trema guineensis Extracts in Acetic Acid Induced in Rats - Open Access Library Journal

OALibJ > Vol.3 No.5, May 2016

Volume 3, Issue 5 (May 2016)

ISSN Print: 2333-9705 ISSN Online: 2333-9721

Google-based Impact Factor: 0.73 Citations

Evaluation of Antalgic Activity and Trace Elements Analysis of Trema guineensis Extracts in Acetic Acid Induced in Rats ()

HTML XML

Download as PDF (Size: 278KB) PP. 1-7

DOI: 10.4236/oalib.1102688 823 Downloads 1,726 Views Citations

Author(s)

Yeboue Koffi F. Kouakou^1*, Houphouet F. Yapi¹, Gnogbo Alexis Bahi¹, Goueh Gnahoue², Allico J. Djaman^1,3

Affiliation(s)

¹Pharmacodynamics Biochemical Laboratory, UFR Biosciences, Felix HOUPHOUET Boigny University, Abidjan, Côte d’Ivoire.
²Laboratory of SVT, Higher Teacher Training School of Côte d’Ivoire, Abidjan, Côte d’Ivoire.
³Laboratory of Basic and Clinical Biochemistry, Pasteur Institute of Côte d’Ivoire, Abidjan, Côte d’Ivoire.

ABSTRACT

We evaluated centrally acting analgesic potential using tail immersion test and peripheral pharmacological actions using acetic acid induced writhing test in rats. The crude extracts of Trema guineensis leave plant were found to have significant analgesic activity at the intraperitoneal dose of 200 mg/kg body weight in two models. In the tail immersion test Trema guineensis increased significantly (P < 0.001) in comparison to the control group (NaCl). The ethanolic (7.57 ± 0.14 s) and aqueous (8.88 ± 0.12 s) extracts reached their maximum in reaction time successively at 30and 45 min. The aim of this study is also to determine the trace elements content in suffering rats of pain induced by acetic acid, using Atomic Spectrophotometer Absorption. Our results showed that trace element concentrations in Trema guineensis ethanolic extract in rats were as follows: Zn (6.92 ± 0.39 mg/L), Fe (37.95 ± 0.04 μmol/L), Cu (8.16 ± 0.12 mg/L) and Mn (0.56 ± 0.12 mg/L). We found following values with aqueous extract compared to NaCl as control: Zn (5.03 ± 0.47 mg/L), Fe (31.08 ± 0.07 μmol/L), Cu (6.69 ± 0.53 mg/L) and Mn (0.51 ± 0.07 mg/L). The intake of trace elements by TGE would lessen the pain generated in acetic acid in rats; this action is much more remarkable with the ethanol extract.

KEYWORDS

Trema guineensis, Oligosol, Trace Elements, Acetic Acid, Pain

Share and Cite:

Kouakou, Y. , Yapi, H. , Bahi, G. , Gnahoue, G. and Djaman, A. (2016) Evaluation of Antalgic Activity and Trace Elements Analysis of Trema guineensis Extracts in Acetic Acid Induced in Rats. Open Access Library Journal, 3, 1-7. doi: 10.4236/oalib.1102688.

Cited by

[1]	Evaluation of nephroprotective activity of aqueous and hydroethanolic extracts of Trema guineensis leaves (Ulmaceae) against gentamicin-induced nephrotoxicity in …
	2017

[2]	Evaluation of Nephroprotective Activity of Aqueous and Hydroethanolic Extracts of Trema guineensis Leaves (Ulmaceae) against Gentamicin-Induced …
	2016

Journals Menu

Follow SCIRP

	+1 323-425-8868
	customer@scirp.org
	+86 18163351462(WhatsApp)
	1655362766

	Paper Publishing WeChat

Journals Menu

Home

About SCIRP

Service

Policies