Author(s)

Aldo Sena de Oliveira¹, Luana Canzian Llanes¹, Inês Maria Costa Brighente¹, Ricardo José Nunes¹, Rosendo Augusto Yunes¹, Nilton Máximo Junior¹, Ana Milda Karsten Baumgart², Anays Noumeh Aust², Alexandre Bella Cruz²

¹Department of Chemistry, Federal University of Santa Catarina, Florianópolis, Brazil.
²Graduate Program in Pharmaceutical Sciences, University of Valley of ltajaí, Itajaí, Brazil.

Nine new sulfonamides derived from carvacrol were prepared through a reaction between 4-hydroxy-2-isopropyl-5-methyl benzene sulfonyl chloride with various amines in excellent yields (76% - 92%). The sulfonamides were characterized using spectrometric and spectroscopic methods. Among these compounds, three derivatives showed excellent results in antibacterial activity against resistant S. aureus strains, with MIC values ranging from 3.9 to 62.50 ppm. The sulfonamide derivative of 4-methylaniline (SULF-1) had the best performance for all tested strains of bacteria (MIC = 3.9 to 15.62 ppm). Furthermore, the sulfonamide derivative of 4-fluoro aniline (SULF-3), which also presented promising results, was found to have a synergistic effect when combined with tetracycline and partial synergistic effect when combined with ampicillin, exhibiting an FIC index between 0.50 and 0.75. The sulfonamide derivative of 4-methylaniline had a synergistic effect in combination with erythromycin exhibiting an FIC index of 0.37. Carvacrol in association with the antibiotics tested did not have a synergistic effect.

Sulfonamides, Carvacrol, Antibacterial, Staphylococcus aureus, Synergism

de Oliveira, A. , Llanes, L. , Brighente, I. , Nunes, R. , Yunes, R. , Máximo Junior, N. , Baumgart, A. , Aust, A. and Cruz, A. (2016) New Sulfonamides Derived from Carvacrol: Compounds with High Antibacterial Activity against Resistant Staphylococcus aureus Strains. Journal of Biosciences and Medicines, 4, 105-114. doi: 10.4236/jbm.2016.47011.