Author(s)

Naoki Watanabe¹, Kana Kawase², Chisato Tawada², Kazufumi Yoneda², Kuniaki Hirai³, Ayumi Niwa¹, Takuji Tanaka^1*

¹Department of Diagnostic Pathology (DDP) & Research Center of Diagnostic Pathology (RC-DiP), Gifu Municipal Hospital, Gifu City, Japan.
²Department of Dermatology, Gifu Municipal Hospital, Gifu City, Japan.
³Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Japan.

Cylindroma is a benign skin appendageal tumor arising from pluripotent stem cells in the follicle. Multiple cylindroma typically occurs as a component of Brooke-Spiegler syndrome or as the only skin lesion of familial cylindromatosis. We herein report an unusual case of multiple cylindroma involving the trunk without any other features of Brooke-Spiegler syndrome and no family history supporting the possibility of familial cylindromatosis. Immunohistochemical features of CYLD and NF-κB, which are involved in the pathogenesis of cylindroma, in the tumors are also presented.

Multiple Cylindroma, Immunohistochemistry, CYLD, NF-κB

Watanabe, N. , Kawase, K. , Tawada, C. , Yoneda, K. , Hirai, K. , Niwa, A. and Tanaka, T. (2016) A Case Report of Multiple Cylindroma with Immunohistochemical Features. Open Journal of Pathology, 6, 134-139. doi: 10.4236/ojpathology.2016.63016.