Author(s)

Behnaz Seyfi¹, Anand P. Santhanam², Olusegun J. Ilegbusi^1*

¹Department of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, Florida, USA.
²Department of Radiation Oncology, University of California, Los Angeles, California, USA.

A biomechanical model is developed and validated for breathing-induced deformation of human lung. Specifically, a subject-specific poro-elastic lung model is used to predict the displacement over the breathing cycle and compared with displacement derived from high resolution image registration. The lung geometry is derived from four-dimensional computed tomography (4DCT) scan dataset of two human subjects. The heterogeneous Young’s modulus is estimated using inverse analysis method. The numerical simulation uses fluid-structure interaction technique to solve the coupled airflow equations and structural dynamics of the lung tissue. The modelled displacement is validated by comparison with the 4DCT registration results.

Biomechanical Model, Lung Deformation, Image Registration

Seyfi, B. , Santhanam, A. and Ilegbusi, O. (2016) A Biomechanical Model of Human Lung Deformation Utilizing Patient-Specific Elastic Property. Journal of Cancer Therapy, 7, 402-415. doi: 10.4236/jct.2016.76043.