Author(s)

Kazuyuki Noguchi¹, Hirayasu Kai¹, Hirofumi Zempo², Fumio Mizuno², Masahiro Hagiwara¹, Naoki Morito¹, Joichi Usui¹, Chie Saito¹, Shinya Kuno², Kunihiro Yamagata^1*

¹Department of Nephrology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
²Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Aim: This study aimed to examine the effects of exercise training on kidney function and nutrition status in obese Chronic Kidney Disease (CKD) patients. Methods: This is a prospective randomized controlled trial. Twelve adult obese CKD patients were randomly assigned to dietary instruction alone group (Group-D) or to both dietary instruction and exercise training group (Group-E). All patients received supervised dietary advice including calorie, protein, and salt intake for a period of 12 weeks. In addition, patients in Group-E underwent a fitness-training program. A change in glomerular filtration rate (GFR) was the main outcome. Secondary outcomes were changes in body mass index, serum creatinine-based estimated-GFR, serum albumin, and albuminuria. Results: Changes in GFR and all secondary outcomes were not statistically significant in either of the two groups. Although exercise training did not appear to significantly affect serum albumin levels in either group, it did present with a large sized effect. Conclusion: Exercise training might not have any effect on kidney function; however, the combination of exercise training along with dietary advice may prove to be more effective in maintaining the nutrition status when compared with dietary instructions alone in obese CKD patients. These results suggest that appropriate exercise training with dietary instructions is recommended for the treatment of obese CKD patients.

CKD, Obesity, GFR, Diet, Exercise Training

Noguchi, K. , Kai, H. , Zempo, H. , Mizuno, F. , Hagiwara, M. , Morito, N. , Usui, J. , Saito, C. , Kuno, S. and Yamagata, K. (2016) Both Diet and Exercise Are Necessary for Obese CKD Patients: A Pilot Prospective Randomized Controlled Study. Open Journal of Nephrology, 6, 43-54. doi: 10.4236/ojneph.2016.62006.