Author(s)

Yuko Yasuhara¹, Tetsuya Tanioka¹, Kensaku Takase², Kazushi Motoki³, Chie Watari⁴, Koichi Makiguchi⁴, Asumi Atsuta⁵, Rozzano C. Locsin¹

¹Institute of Biomedical Sciences, Graduate School, Tokushima University, Tokushima, Japan.
²Tokushima Prefectural Central Hospital, Tokushima, Japan.
³Tokushima Prefectural Kaifu Hospital, Tokushima, Japan.
⁴Fujishiro Kensei Hospital, Hirosaki, Japan.
⁵Graduate School of Health Sciences, Tokushima University, Tokushima, Japan.

The aim of this study was to consider the characteristics of intramuscular diffusion status of risperidone and aripiprazole long acting injectable (LAI) by ultrasonography. Subjects were 40 adult subjects diagnosed with schizophrenia and treated with LAI [32 patients were risperidone LAI (RLAI) and 8 patients were aripiprazole LAI (ALAI)]. However, in this paper, only three cases (one RLAI case and 2 ALAI cases) were selected to illustrate the diffusion effects of both LAI. Dorsogluteal intramuscular (IM) injection sites were measured at prone position using the “double cross” method. Before LAI injection, the distance from the epidermis to the under-fascia (DEUF), and distance from the epidermis to the iliac bone (DEI) at the IM injection site were assessed by using ultrasonography: 1) the injection needle was inserted to the gluteus medius, and 2) observed the diffusion status within the muscle injected RLAI and ALAI were confirmed using the B-mode ultrasonography. Both RLAI and ALAI were depicted as high echogenicity with acoustic shadowing. It was considered that the diffusion states of LAIs by ultrasonography were important time course evaluations providing objective evidence.

Diffusion Status, Risperidone, Aripiprazole, Long Acting Injectable (LAI), Ultrasonography

Yasuhara, Y. , Tanioka, T. , Takase, K. , Motoki, K. , Watari, C. , Makiguchi, K. , Atsuta, A. and Locsin, R. (2016) Intramuscular Diffusion Status of Risperidone and Aripiprazole Long Acting Injectable (LAI) by Ultrasonography. Open Journal of Psychiatry, 6, 165-172. doi: 10.4236/ojpsych.2016.62020.