Author(s)

Dally Najib^1,2, Daniel Talmud³, Saher Srour^2,4, Rola Khamisy-Farah⁵, Raymond Farah^1,2*

¹Department of Hematology, Ziv Medical Center, Zefat, Israel.
²Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel.
³Department of Internal Medicine, Ziv Medical Center, Zefat, Israel.
⁴Department of Radiology, Ziv Medical Center, Zefat, Israel.
⁵Clalit Health Service, Akko, Israel.

We report the case of a 56-year-old female who had recently been examined for back and epigastric pain, and was diagnosed in the internal medicine ward as having an aggressive rare form of multiple myeloma with diffuse osteoblastic bone lesions. She also had high levels of breast tumor marker (CA 15-3), severe tumor lysis syndrome, and pleural and central nervous system involvement. A few cases of multiple myeloma with diffuse osteosclerosis that are not part of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changeshave) have been described. None of these cases were as aggressive as our case. To our knowledge it is the first report describing an elevation in CA 15-3 in conjunction with multiple myeloma.

Multiple Myeloma, Osteosclerosis, CA 15-3, Pleural Effusion

Najib, D. , Talmud, D. , Srour, S. , Khamisy-Farah, R. and Farah, R. (2016) Rare Aggressive Form of Multiple Myeloma with Diffuse Osteosclerosis and Elevated CA 15-3 Levels. Open Journal of Internal Medicine, 6, 11-14. doi: 10.4236/ojim.2016.61003.