Prognostic Significance of Standardized Uptake Value of PET Scan in Non-Small Cell Lung Cancer ()
ABSTRACT
Background: To determine if the maximum standardized uptake value (SUVmax)
of the primary tumor as determined by preoperative (18)F-fluoro-2-deoxyglucose
((18)F-FDG) positron emission tomography (PET) is an independent predictor of
overall survival, mediastinal lymph node metastasis, and stage in patients with
non-small cell lung cancer (NSCLC). Methods: A retrospective review of 1033
patients with stage I-IV histologically proven NSCLC who had an (18)F-FDG PET
done between 2005 and 2011 for staging before receiving therapy was performed.
SUVmax of primary NSCLC was measured and
correlated with tumor characteristics, lymph node involvement, cancer
stage and overall survival. The patients were divided into three groups
according to their SUVmax value: group I SUVmax < 5; group II SUVmax 5 - 10;
and group III SUVmax > 10. The primary outcome was survival and recurrence
rate, compared using Log Rank Test. Results: The median duration of follow up
was 675 days (22.5 months). The overall survival at two years for group I was
88%, group II 60% and group III 53%, significantly different among the three
groups (p-value < 0.0001). Earlier stage lung cancer was found in patients
with lower SUVmax values: in group I, 73% of patients had stage I cancer and
only 4% had stage IV. The rate of ipsilateral mediastinal lymph node
involvement (N2) in group I was 12.9% compared to 44.4% in group III (p-value <
0.0001). The overall survival was significantly different between group I and
group II (Hazard Ratio (HR) 3.6; 95% C.I 2.2 - 5.7 and a p-value < 0.0001)
and between group II and group III (HR 1, 4; 1.1 - 1.8 and a p-value = 0.013). Conclusion:
There was a statistically significant difference in the overall survival,
mediastinal lymph node metastases, and higher cancer stage with greater values
of SUVmax on PET scan in patients with NSCLC.
Share and Cite:
Alshuhayeb, A. , Gilbert, S. , Seely, A. , Shamji, F. , Sundaresan, S. , Villeneuve, P. and Maziak, D. (2016) Prognostic Significance of Standardized Uptake Value of PET Scan in Non-Small Cell Lung Cancer.
Journal of Cancer Therapy,
7, 186-196. doi:
10.4236/jct.2016.73019.
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