Author(s)

Sanjeev Kumar^1*, Reena Mittal², Shweta Chaudhary¹, Deep Chand Jain³

¹Department of Physics, Central Medical Physics Research Laboratory, D.A.V. (P.G.) College, Muzaffar Nagar, India.
²Department of Mathematics, K.K. Jain College, Muzaffar Nagar, India.
³Department of Neurology, Safdarganj Hospital, New Delhi, India.

Atomic absorption analysis involves measuring the absorption of light by vaporized ground state atoms and relating the absorption to concentration. The incident beam of light is attenuated by atomic vapour absorption according to Beer’s Law. The estimation of trace elements shows a colorful presentation of different metals. It has been seen and found that the levels of zinc, calcium, magnesium, aluminum are lower in Alzheimer’s disease samples in comparison to healthy controls. The elements such as copper, iron, potassium and sodium were found higher than controls. A statistical analysis has been applied and measured regression with correlation coefficients including multiple correlation coefficients between different trace elements like Na, K, Ca, Mg, Zn, Cu, Fe and Al in normal samples. A trend has been found in coefficient of correlation such as r_Ca.Mg > r_Na.K > r_Cu.Zn > r_Zu.Al > r_Cu.Fe > r_Cu.Al with positive correlation and r_Fe.Al > r_Fe.Zn with negative correlation. Coefficient of partial correlation is also calculated and found that a trend has been set up between trace elements and given here as r_NaK.Mg > r_ZnCu.Fe > r_NaK.Ca > r_CuFe.Zn with positive correlation and r_ZnFe.Cu > r_ZnFe.Al > r_MgNa.K > r_CaNa.K > r_MgK.Na > r_CaK.Na with negative correlation. Multiple correlation coefficient in normal healthy person has been estimated and found that a trend, which is given here as R_Zn.FeCu > R_Fe.CuZn > R_Zn.FeAl > R_K.MgNa > R_Na.MgK > R_Cu.FeZn > R_Na.KCa > R_K.NaCa > R_Ca.KNa > R_Mg.NaK. Multiple correlation coefficient in AD samples has been estimated and found that a trend, which is given here as R_Fe.CuZn > R_Zn.FeCu > R_Cu.FeZn > R_Na.KCa > R_K.NaCa > R_Ca.KNa > R_Na.MgK > R_K.MgNa > R_Zn.FeAl > R_Mg.NaK.

Alzheimer’s Disease, Trace Elements, Flame Atomic Absorption, Multiple and Partial Correlation Coefficients and Regression Equations

Kumar, S. , Mittal, R. , Chaudhary, S. and Jain, D. (2014) Role of Trace Elements in Alzheimer’s Disease. Open Access Library Journal, 1, 1-30. doi: 10.4236/oalib.1100714.