Author(s)

Michael Losos¹, Basil M. Kahwash², Miriam Conces³, Joel Thompson⁴, Riten Kumar⁴, Samir B. Kahwash^3*

¹Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
²Indiana University, Indianapolis, IN, USA.
³Department of Pathology and Laboratory Medicine, Nationwide Children’s Hospital, Columbus, OH, USA.
⁴Department of Pediatrics, The Ohio State University, Division of Hematology/Oncology/BMT, Nationwide Children’s Hospital, Columbus, OH, USA.

Jacobsen syndrome (JS) is a rare, inherited disorder, characterized by facial and skull dysmorphism, mental retardation, and platelet abnormalities. Paris-Trousseau syndrome (PTS) is a platelet function disorder that may be encountered in patients affected by JS. PTS is manifested by a mild lifelong bleeding tendency. Morphologically, the presence of large fused platelet alpha granules is characteristic. We present a case of Jacobsen syndrome in a child and highlight the typical morphologic and ultrastructure findings of platelets.

Jacobsen Syndrome, Paris-Trousseau Syndrome, Platelet Microscopic Findings, Electron Microscopy

Losos, M. , Kahwash, B. , Conces, M. , Thompson, J. , Kumar, R. and Kahwash, S. (2016) Jacobsen/Paris-Trousseau Syndrome: Report of a Case with Emphasis on Platelet’s Light Microscopic and Ultrastructure Findings. Open Journal of Pathology, 6, 8-13. doi: 10.4236/ojpathology.2016.61002.