International Journal of Organic Chemistry

Volume 5, Issue 4 (December 2015)

ISSN Print: 2161-4687   ISSN Online: 2161-4695

Google-based Impact Factor: 1.26  Citations  

Green and High Efficient Synthesis of 2-Aryl Benzimidazoles: Reaction of Arylidene Malononitrile and 1,2-Phenylenediamine Derivatives in Water or Solvent-Free Conditions

HTML  XML Download Download as PDF (Size: 338KB)  PP. 256-263  
DOI: 10.4236/ijoc.2015.54025    5,281 Downloads   7,940 Views  Citations

ABSTRACT

A fast, high efficiency and environmentally friendly procedure for the synthesis of 2-aryl benzim-idazole derivatives has been reported. Reaction between 1,2-phenylenediamine derivatives and arylidene malononitrile under aqueous media and also solvent-free conditions generates 2-aryl benzimidazole derivatives with a high yield.

Share and Cite:

Habibi, A. , Valizadeh, Y. , Mollazadeh, M. and Alizadeh, A. (2015) Green and High Efficient Synthesis of 2-Aryl Benzimidazoles: Reaction of Arylidene Malononitrile and 1,2-Phenylenediamine Derivatives in Water or Solvent-Free Conditions. International Journal of Organic Chemistry, 5, 256-263. doi: 10.4236/ijoc.2015.54025.

Cited by

[1] Preferential Synthesis and Pharmacological Evaluation of Mono‐and Di‐substituted Benzimidazole Derivatives
, 2022
[2] Cooperative catalysis: Condensation-aromatization for synthesis of 2-(4-nitrophenyl)-1H-benzimidazole by silica immobilized Brønsted-Lewis acidic ionic liquid (Si …
Journal of the Indian Chemical Society, 2022
[3] Green synthesis of Schiff bases: a review study
Iraqi Journal of Pharmacy, 2022
[4] Synthesis of Benzimidazole Derivatives and their Biological Investigation
2021
[5] Synthesis of benzimidazole by mortar–pestle grinding method
Green Chemistry Letters …, 2021
[6] Synthesis of novel bis‐and poly (benzimidazoles) as well as bis‐and poly (benzothiazoles) as anticancer agents
2020
[7] A new efficient synthesis of thiazolidine derivatives in the presence of Fe3O4@SiO2–SO3H nanoparticles as a magnetically separable catalyst
2019
[8] Synthesis of thiazolidine derivatives via multicomponent reaction in the presence of Fe3O4@ SiO2-SO3H nanoparticles as a heterogeneous catalyst
2019
[9] Aqueous solvent as a safe and eco-friendly medium for the clean synthesis of furo [2, 3-d] pyrimidines
2018
[10] Green methods for synthesis of various Heterocycles: Sustainable approach
2017
[11] Promising Synthetic Approaches Using Aqueous Media for Assembling Various Substituted Benzimidazoles

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.