Author(s)

Yousuke Watanabe¹, Nobuo Yamaguchi^1,2*, Isao Horiuch^3,4, Tsugia Murayama⁵

¹Ishikawa Natural Medicinal Products Research Center, Ishikawa, Japan.
²Department of Fundament Research for CAM, Kanazawa Medical University, Ishikawa, Japan.
³Traditional Uighur Medicine Department, Xinjiang Medical University, Urumchi, China.
⁴Traditional Chinese Medicine Hospital, Xinjiang Medical University, Urumchi, China.
⁵Faculty of Pharmaceutical Sciences, Department of Microbiology and Immunology, Hokuriku University, Ishikawa, Japan.

A plant fermentation was carried out by Yeast and Lactobaccilli against fermented black turmeric, Kaempferia parviflora (FBT). These materials were proved by as safe in animal safety experiment. We tried to investigate changes of immune-competent cells that commonly utilized FBT, including after administration of immno-suppressed animals, the effects by FBT on the regulated effect on the cells were evaluated. Our results showed that FBT augmented the level of lymphocytes in number, while FBT regulated the level of granulocytes in both number and function. In our clinical study with 20 healthy volunteers, granulocyte and lymphocyte ratio suggesting their constitution as neutral in peripheral blood were increased significantly 30 days after the administration of FBT in rodents, and compromised host was prepared with cancer chemotherapeutic agent (Mytomycin-C). Our observations showed against intracellular parasite, and that FBT augmented intercellular pathogen through humoral immunity. We discussed the significance and mechanism of FBT on the level of leukocyte subsets in number and function that were considered to be potential indicators for the activation of the compromised host. We also proposed an idea that FBT exhibited tonic effects via activating complement components. The evidences were shown by immune-electrophoretic method. Moreover, we tried to access further to the anti-oxidative activities of this FBT. This modification brought to the significant lift up for antibody producing cells and anti-oxidative activity for phagocytic cells.

Family Turmeric Lactobacillus, Fermentation, Lactobacilli, Cancer, Chemotherapeutic Agent, Compromised Host, Complement, Alternative Complement Activation

Watanabe, Y. , Yamaguchi, N. , Horiuch, I. and Murayama, T. (2015) Fermented Black Turmeric Designed by Lactobacillus Rearranged Leukocyte Subsets and Anti-Oxidative Activity. Open Journal of Immunology, 5, 199-214. doi: 10.4236/oji.2015.53016.