Author(s)

Patricio Rioseco S¹, Sergio Tapia Z¹, Verónica Céspedes S², Juan Pablo Silva C³, Paulina Lozano F³

¹Respiratory Unit, Hospital Las Higueras, Talcahuano, Chile.
²Transfusional Medicine Unit, Hospital Las Higueras, Talcahuano, Chile.
³Internal Medicine, Universidad de Concepciòn, Concepciòn, Chile.

The use of PRP involves a complex network of molecular events which accelerate tissue regenera-tion due to its richness in growth factors plus a variety of biologic mediators. Several communica-tions tell us about its usefulness on the dental implantology field, plastic surgery, orthopedics and peripheral nerve regeneration after trauma. We have presented our successful experience of its use in pneumology when treating severe hemoptysis, respiratory fistulae, spontaneous pneumothorax and one tracheal rupture. In this article we present two cases of post intubation tracheal rupture successfully treated with the local instillation of PRP on one of them and with the injection of PRP along the lips of the tracheal wound on the other. Tracheal rupture is a rare but life threatening complication of emergency intubation requiring an effective response in order to avoid the risk of patient death due to secondary mediastinitis and sepsis. Up to now there is no general consensus in the treatment of this condition and alternatives in use are not universally accepted. The use of local autologous PRP in our experience has demonstrated a favorable performance in such cases, turning it in a highly promising tool for the treatment of conditions such as this, in which a rapidly effective and minimally invasive handling is required.

Tracheal Rupture, Endotracheal Intubation, Platelet Rich Plasma

Rioseco S, P. , Tapia Z, S. , Céspedes S, V. , Silva C, J. and Lozano F, P. (2015) Use of Platelet Rich Plasma (PRP) in the Treatment of Acute Post Intubation Tracheal Rupture: Report of Two Cases. International Journal of Clinical Medicine, 6, 487-495. doi: 10.4236/ijcm.2015.67065.