Successful High-Dosage Dexamethasone Treatment of H1N1 Influenza A Pneumonia Complicated with Acute Necrotizing Encephalitis in an HIV-Infected Adult - Case Reports in Clinical Medicine

CRCM > Vol.4 No.7, July 2015

Volume 4, Issue 7 (July 2015)

ISSN Print: 2325-7075 ISSN Online: 2325-7083

Google-based Impact Factor: 0.2 Citations

Successful High-Dosage Dexamethasone Treatment of H1N1 Influenza A Pneumonia Complicated with Acute Necrotizing Encephalitis in an HIV-Infected Adult ()

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DOI: 10.4236/crcm.2015.47048 2,851 Downloads 3,801 Views

Author(s)

Kuan-Chih Chen¹, Chien-Hung Gow², Chia-Jui Yang³, Hou-Tai Chang²

Affiliation(s)

¹Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City.
²Department of Internal Medicine, Division of Pulmonary Medicine, Far Eastern Memorial Hospital, New Taipei City.
³Department of Internal Medicine, Division of Infection Disease, Far Eastern Memorial Hospital, New Taipei City.

ABSTRACT

Neurological manifestations in H1N1 influenza A infection are very rare, especially in adults, and its mechanism of action is still uncertain. Here, we reported the case of a 53-year-old woman with human immunodeficiency virus infection (HIV) who had H1N1 influenza A pneumonia complicated with very rare acute necrotizing encephalitis, although the HIV was under control. With prompt identification and administration of high dosage of dexamethasone, her mental status improved from stupor to clear, with minimal right hemiparesis. Further, brain magnetic resonance image revealed great resolution of mass effect. This dramatic improvement in response to the treatment may improve our understanding of the pathophysiology between H1N1 influenza A infection and acute necrotizing encephalitis.

KEYWORDS

H1N1 Influenza A Pneumonia, Acute Necrotizing Encephalitis, Human Immunodeficiency Virus

Share and Cite:

Chen, K. , Gow, C. , Yang, C. and Chang, H. (2015) Successful High-Dosage Dexamethasone Treatment of H1N1 Influenza A Pneumonia Complicated with Acute Necrotizing Encephalitis in an HIV-Infected Adult. Case Reports in Clinical Medicine, 4, 245-249. doi: 10.4236/crcm.2015.47048.

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