Fibrolamellar Carcinoma: A Distinct Variant of Hepatocellular Carcinoma That Is Still Surrounded by Unveils Mysteries - Journal of Cancer Therapy

JCT > Vol.5 No.14, December 2014

Volume 5, Issue 14 (December 2014)

ISSN Print: 2151-1934 ISSN Online: 2151-1942

Google-based Impact Factor: 0.30 Citations h5-index & Ranking

Fibrolamellar Carcinoma: A Distinct Variant of Hepatocellular Carcinoma That Is Still Surrounded by Unveils Mysteries ()

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DOI: 10.4236/jct.2014.514132 4,858 Downloads 6,455 Views Citations

Author(s)

Consolato Sergi^1,2*

Affiliation(s)

¹Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.
²Department of Pediatrics, Stollery Children’s Hospital, Edmonton, Canada.

ABSTRACT

Fibrolamellar carcinoma (FL-HCC) is overall a quite rare variant of hepatocellular carcinoma (HCC) that is intriguing and poorly understood at same time. In humans, it affects essentially the young population (children and young adults) in the peculiar absence of underlying liver diseases. FL-HCC has distinctive clinico-pathologic features with metastases frequently found in the regional lymph nodes, but also peritoneum and lungs. Although initially considered harboring an indolent course, survival outcomes have been recently updated pointing to a neoplasm concealing many aspects of biogenesis. In this review, morphology, molecular pathways, and prognosis of this rare tumor are presented.

KEYWORDS

Liver, Tumor, Carcinoma, Pathogenesis, Differential Diagnosis, Therapy, Prognosis

Share and Cite:

Sergi, C. (2014) Fibrolamellar Carcinoma: A Distinct Variant of Hepatocellular Carcinoma That Is Still Surrounded by Unveils Mysteries. Journal of Cancer Therapy, 5, 1325-1331. doi: 10.4236/jct.2014.514132.

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