Resveratrol—The “Chateau Hormone” for Cardio Diabetic Protection - Journal of Diabetes Mellitus

JDM > Vol.4 No.4, November 2014

Journal of Diabetes Mellitus

Volume 4, Issue 4 (November 2014)

ISSN Print: 2160-5831 ISSN Online: 2160-5858

Google-based Impact Factor: 0.48 Citations

Resveratrol—The “Chateau Hormone” for Cardio Diabetic Protection ()

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Download as PDF (Size: 3200KB) PP. 371-378

DOI: 10.4236/jdm.2014.44050 3,408 Downloads 4,351 Views Citations

Author(s)

Manish Maladkar^*, Meenu Awatramani, Kundan Bhong

Affiliation(s)

Aristo Pharmaceuticals Pvt. Ltd., Mumbai, India.

ABSTRACT

Resveratrol is a naturally occurring phenolic compound abundantly found in grape skin and in wines. Resveratrol is a phytoalexin trans-3,5,4’-trihydroxystilbene that possesses diverse biochemical and physiological actions. It is effective in improving health and preventing or treating chronicdiseases. The cardiovascular protective effects of Resveratrol suggest the anti-atherogenic and anti-inflammatory activity of the compound on endothelial cells. Resveratrol attenuates myocardial ischemic reperfusion injury, atherosclerosis and reduces ventricular arrhythmias. Resveratrol has been widely studied and is shown to have anti-oxidant, anti-inflammatory, anti-proliferative and anti-angiogenic effects and many signalling pathways are among the molecular targets of Resveratrol. Based on these mechanistic considerations, the involvement of Resveratrol has been observed in cardiovascular diseases, cancer and neurodegenerative diseases. In type 2 diabetes patients, when Resveratrol was given along with anti-diabetic agents, it was found to lower blood glucose, HbA1C and increase the insulin sensitivity and the levels of HDL-C. Resveratrol acts on the SIRT1 gene and stimulates endogenous pathways to promote health and longevity.

KEYWORDS

Resveratrol, Cardiovascular Disease, Atherosclerosis, HDL-C, Diabetes, β-Blockers, Residual Vascular Risk

Share and Cite:

Maladkar, M. , Awatramani, M. and Bhong, K. (2014) Resveratrol—The “Chateau Hormone” for Cardio Diabetic Protection. Journal of Diabetes Mellitus, 4, 371-378. doi: 10.4236/jdm.2014.44050.

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