Author(s)

Tatyana Rocheva¹, Vladimir Tyurin², Dmitrii Belykh¹, Аnna Moiseeva², Jingwei Zhang², Еvgeny Buravlev¹, Irina Chukicheva¹, Alexander Alexander Kutchin¹, Elena Milaeva^2,3*

¹Institute of Chemistry, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, Syktyvkar, Russia.
²Department of Medicinal Chemistry and Fine Organic Synthesis, Lomonosov Moscow State University, Moscow, Russia.
³Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia.

The complexes of biogenic metals (Zn²⁺,Cu²⁺,Co²⁺,Mn³⁺,Fe³⁺) based on meso-tetra(3,5-diisobor- nyl-4-hydroxyphenyl)porphyrin 1 were synthesized. The electrochemical behavior of these com-pounds was studied using cyclic voltammetry (CV) and rotating disk electrode (RDE) techniques. The antioxidant activity of complexes was estimated by means of the electrochemical assay based on the hydrogen atom transfer reaction to the stable radical 2,2’-diphenyl-1-picrylhydrazyl (DPPH). The RDE method was applied for this process monitoring. It was shown that the efficiency of the metal complexes (Cu²⁺,Co²⁺,Mn²⁺,Ni²⁺,Fe³⁺) is practically the same order as that of free base porphyrin 1. However the Zn²⁺ complex demonstrates significantly higher antioxidant activity, and the stoichiometry of the reaction was determined as σ = 4. The results demonstrate that porphyrin macrocycle can directly affect the antioxidant properties of 2,6-diisobornylphenol.

Metal Porphyrins, Cyclic Voltammetry, Rotating Disk Electrode, 2, 2’-Diphenyl-1-picrylhydrazyl, Antioxidant Activity

Rocheva, T. , Tyurin, V. , Belykh, D. , Moiseeva, А. , Zhang, J. , Buravlev, Е. , Chukicheva, I. , Alexander Kutchin, A. and Milaeva, E. (2014) The Application of Novel Electrochemical Approach to Antioxidant Activity Assay of Metal Porphyrins with Bulky 3,5-Diisobornyl-4-hydroxyphenyl Moieties. American Journal of Analytical Chemistry, 5, 1028-1036. doi: 10.4236/ajac.2014.515109.