Infections and inflammatory responses are linked to 20% - 300% of all deaths from cancer worldwide. Inflammatory responses play crucial roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Several studies point to an important role of inflammation in prostate growth, although the contribution of inflammation to benign prostate cancer is not completely understood. The basic and clinical research in the area, trying to understand the etiology of prostatic inflammation and its signaling pathway may help to develop the novel therapeutic interventions against prostate cancer development triggered by inflammation.