For enhancing the activity of Ni/TiO₂-SAPO-11 catalyst, SAPO-11, the precursor was prepared by hydrothermal crystallization, and TiO₂-SAPO-11 complex carrier was prepared by sol-gel method, then Ni/TiO₂-SAPO-11 was produced by the final product. The catalytic performance of Ni/TiO₂-SAPO-11 was studied in n-heptane isomerization, and the impact of catalyst preparation conditions on n-heptane isomerization was discussed in detail. The results showed that, with 20% of TiO₂ composition, 2% of Ni capacity percentage and calcined temperature at 500°C, conversion of n-heptane and isomerization selectivity was up to 40.94% and 88.97% respectively.