Effect of Slice Thickness Reconstruction on Quantitative Vascular Parameters in Perfusion CT ()
ABSTRACT
Objective: The purpose of this study was to determine
how the slice thickness reconstruction influences quantitative perfusion CT
parameters. Materials and Methods: Eighteen patients with cancer (15 non-small-cell
lung cancer, 2 rectal cancer and 1 renal cancer) were examined prospectively
with multidetector row CT. A 90-second perfusion study was performed after
intravenous bolus injection of contrast material. Blood flow, blood volume,
mean transit time and permeability-surface area product were determined at
three different slice thickness reconstruction (1.25, 2.5 and 5 mms) both in
tumors and in paraspinal muscle. Mean values, limits of agreement between
measurements and within-subject coefficient of correlation were obtained for
these thicknesses. Results: Mean ± standard deviation BF, BV, MTT and PS in
lesions were 118.7 ± 117.9 mL/min/100g tissue, 8.2 ± 8.2 mL/100g tissue, 7.5 ±
5.4 seconds and 10.3 ± 7.2 mL/min/100g tissue respectively at1.25 mmslice thickness;
116.1 ± 115.7 mL/min/100g tissue, 7.8 ± 8.7 mL/100g tissue, 7 ± 4.5 seconds and
10.4 ± 7.5 mL/min/100g tissue at 2.5 mms; and 119.6 ± 115.7 mL/min/100g tissue,
7.8 ± 8.8 mL/100g tissue, 5.4 ± 3.4 seconds and 9.6 ± 7.5 mL/min/100g tissue at
5 mms. Differences between means for different slice thickness where relatively
small in all parameters (<15%) except in MTT where difference was up to 37%.
95% limits of agreement were worse when comparing more different slice
thicknesses (e.g. 1.25 vs 5 mms) than when comparing more close slice
thicknesses (1.25 vs 2.5 mms or 2.5 vs 5 mms). Conclusions: There is a
significant variability in perfusion parameter measurements at different slice
thickness reconstruction, particularly in MTT. The more close together the
slice thicknesses were, the smaller was the variability.
Share and Cite:
Martínez-de-Alegría, A. , García-Figueiras, R. , Baleato-González, S. , Rodriguez-Alvarez, M. , Martínez-Souto, I. and Villalba-Martín, C. (2014) Effect of Slice Thickness Reconstruction on Quantitative Vascular Parameters in Perfusion CT.
Open Journal of Radiology,
4, 53-59. doi:
10.4236/ojrad.2014.41007.