Author(s)

Ronbinson Enow Mbu, Yao Raphaël Abauleth, Akpadza Koffi, Namory Keita, Amadou Dolo, Jean Lankoande

Department of Obstetrics and Gynecology, Cocody University and Hospital, Boulevard de l’Université de Cocody, Abidjan, C?te d’Ivoire.
Department of Obstetrics and Gynecology, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroun.
Department of Obstetrics and Gynecology, Gabriel Touré University Hospital, Bamako, Mali.
Department of Obstetrics and Gynecology, Tokoin University Hospital, 198 rue de l’h?pital, Lome, Togo.
Department of Obstetrics and Gynecology, University of Conakry and DONKA Hospital, Conakry, Republique de Guinée.
Department of Obstetrics and Gynecology, Yalgado Ouédraogo University Hospital, Avenue du capitaine Thomas Sankara, Ouaga- dougou, Burkina Faso.

The aim of this study was to evaluate the effectiveness of a pharmaceutical grade isoflavone supplement (Inoclim^?) 40 mg per capsule of soy extract rich in daidzin and genistin) on the number of hot flashes and night sweats in menopausal African women. This open, prospective, multicenter study involved 140 menopausal women with climacteric symptoms (i.e., a minimum of five hot flashes and/or moderate to severe night sweats per day). These patients received a daily 40-mg supplement of soy isoflavone contained in an Inoclim^? capsule (Laboratoire Innotech International, France). The dose was increased to two capsules per day when there were more than five hot flashes or when the women could not sleep because of night sweats. The patients were followed up over a 4-month period and data were analyzed using EPI-Info^TM version 3.5.1. The outcome measure was fewer hot flashes and night sweats. The mean daily number of episodes of hot flashes was 5.7 at baseline and 1.8 at week 16, corresponding to a decrease of 68.4% (n = 93 patients at baseline and n = 66 at 16 weeks). The mean number of daily episodes of night sweats was 3.7 at baseline and 0.8 at week 16, corresponding to a decrease of 78.4% (n = 127 patients in the first week and n = 73 at 16 weeks). Over 80% of patients took a single one 40 mg capsule per day. The percentage of patients who adhered to the prescription was more than 95% during the 4-month follow-up period. These results confirm the effectiveness of a pharmaceutical grade isoflavone supplement (40 mg, rich in genistin and daidzin) on vasomotor symptoms in menopausal women.

Menopause; Climacteric Disorders; Hot Flashes; Night Sweats; Soy Isoflavones; Genistin, Daidzin; Genistein; Daidzein; Inoclim

Mbu, R. , Abauleth, Y. , Koffi, A. , Keita, N. , Dolo, A. and Lankoande, J. (2014) Effect of daily supplementation of soy isoflavones on hot flashes and night sweats in African menopausal women. Open Journal of Obstetrics and Gynecology, 4, 42-46. doi: 10.4236/ojog.2014.41008.